Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


France: Succicaptal; Greece: Succicaptal.

North America

USA: Chemet.

Drug combinations


Succimer: C~4~H~6~O~4~S~2~. Mw: 182.22. (1) Butanedioic acid, 2,3-dimercapto-, (R*,S*)-; (2) meso-2,3-Dimercaptosuccinic acid. CAS-304-55-2 (1978).

Pharmacologic Category

Heavy Metal Antagonists. Antidotes. (ATC-Code: V03AB).

Mechanism of action

An analog of dimercaprol. Forms water soluble chelates with heavy metals which are subsequently excreted renally. Binds heavy metals.

Therapeutic use

Lead poisoning in children with serum lead levels >45 µg/dL.

Pregnancy and lactiation implications

Following maternal occupational exposure, lead crosses placenta in amounts related to maternal plasma levels and may cause spontaneous abortion, postnatal developmental delay, and reduced birth weight. Chelation therapy during pregnancy is for maternal benefit only and should be limited to treatment of severe, symptomatic lead poisoning. Excretion in breast milk unknown (not recommended in nursing women). Calcium supplementation may reduce amount of lead in breast milk.

Unlabeled use

Lead poisoning in symptomatic adults.


Hypersensitivity to succimer or any component of the formulation.

Warnings and precautions

Not used to prevent lead poisoning. Does not cross blood-brain barrier and should not be used to treat encephalopathy associated with lead toxicity. Use with caution in hepatic/renal impairment. Succimer is dialyzable; however, lead chelates are not. Rebounding serum lead levels may occur after treatment as lead is released from storage sites into blood. May cause false-positive ketones using nitroprusside methods, falsely decreased serum CPK, and falsely decreased uric acid measurement.



Legal Notice
Privacy Policy
Cookie Policy


Phone: +34-981-780505
Location: Sta Marta de, C. P. Babío, S/N, 15165 Bergondo, A Coruña

Copyright © 2023 WAGEM

Add to cart