Sulfisoxazole
- Atc Codes:J01EB05
- CAS Codes:80-74-0
- PHARMGKB ID:80-74-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
Canada: Sulfisoxazole; USA: Sulfisoxazole.
Asia
Japan: Thiasin.
Drug combinations
Sulfisoxazole and Erythromycin
Chemistry
Sulfisoxazole Acetyl: C~13~H~15~N~3~O~4~S. Mw: 309.34. (1) Acetamide, N-[(4-aminophenyl)sulfonyl]-N-(3,4-dimethyl-5-isoxazolyl)-; (2) N-(3,4-Dimethyl-5-isoxazolyl)-N-sulfanilylacetamide. CAS-80-74-0.
Pharmacologic Category
Antibacterials; Sulfonamides. (ATC-Code: J01EB05).
Mechanism of action
Interferes with bacterial growth by inhibiting bacterial folic acid synthesis through competitive antagonism of p-aminobenzoic acid.
Therapeutic use
Urinary tract infections, otitis media, Chlamydia, nocardiosis.
Pregnancy and lactiation implications
Contraindicated in pregnancy. Enters breast milk (compatible with lactation).
Unlabeled use
Contraindications
Hypersensitivity to sulfisoxazole, any sulfa drug, or any component of the formulation. Porphyria. Infants <2 months of age (sulfas compete with bilirubin for protein-binding sites). Urinary obstruction. Sunscreens containing para-aminobenzoic acid. Pregnancy (at term).
Warnings and precautions
Agranulocytosis, aplastic anemia and other blood dyscrasias occurred. Fatalities associated with severe reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis occurred. Fatalities associated with hepatic necrosis occurred. Chemical similarities are present among sulfonamides, sulfonylureas, carbonic anhydrase inhibitors, thiazides, and loop diuretics (except ethacrynic acid). Risk of cross-reaction exists in allergy to any of these compounds (avoid use when previous reaction severe). Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Use with caution in G6PD deficiency (hemolysis may occur), and in hepatic or renal impairment. Risk of crystalluria should be considered.