Talc
- CAS Codes:14807-96-6
- PHARMGKB ID:14807-96-6
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Dosage
- Special Considerations
Brand Names
North America
USA: Sclerosol, Talc.
Drug combinations
Talc: Ergocalciferol (Vitamin D~2~); Retinol (Vitamin A); Riboflavin (Vitamin B~2~)
Chemistry
Talc (talk): CAS-14807-96-6.
Pharmacologic Category
Sclerosing Agents.
Mechanism of action
Induces inflammatory reaction which promotes adherence of visceral to parietal pleura, therefore preventing reaccumulation of pleural fluid.
Therapeutic use
Prevention of recurrence of malignant pleural effusion in symptomatic patients.
Pregnancy and lactiation implications
Use only if potential benefit outweighs possible risk to fetus.
Unlabeled use
Contraindications
Warnings and precautions
Acute pneumonitis and acute respiratory distress syndrome (including one death) rarely reported with higher doses (10 g). Should not be used to treat malignancies. Does not have antineoplastic activity. Sclerosis of pleural space may preclude subsequent procedures (e.g. pneumonectomy for transplantation).