Tazarotene
- Atc Codes:D05AX05
- CAS Codes:118292-40-3
- PHARMGKB ID:118292-40-3
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
France: Zorac; Germany: Zorac; Greece: Zorac; Ireland: Zorac; Italy: Zorac; Poland: Zorac; Spain: Zorac; UK: Zorac.
North America
Canada: Tazorac; USA: Avage, Tazorac.
Latin America
Mexico: Tazmeral.
Drug combinations
Chemistry
Tazarotene: C~21~H~21~NO~2~S. Mw: 351.46. (1) 3-Pyridinecarboxylic acid, 6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-,ethylester; (2) Ethyl 6-[(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinate. CAS-118292-40-3 (1994).
Pharmacologic Category
Skin and Mucous Membrane Agents, Miscellaneous. Keratolytic Agent. Topical Skin Product (Acne). (ATC-Code: D05AX05).
Mechanism of action
Synthetic, acetylenic retinoid which modulates differentiation and proliferation of epithelial tissue and exerts some degree of anti-inflammatory and immunological activity.
Therapeutic use
Topical treatment of facial acne vulgaris. Topical treatment of stable plaque psoriasis. Mitigation (palliation) of facial skin wrinkling, facial mottled hyper-/hypopigmentation, and benign facial lentigines.
Pregnancy and lactiation implications
May cause fetal harm if administered to a pregnant woman. Excretion in breast milk unknown (use with caution in nursing women).
Unlabeled use
Contraindications
Hypersensitivity to tazarotene, other retinoids or vitamin A derivatives (isotretinoin, tretinoin, etretinate), or any component of the formulation. Pregnancy.
Warnings and precautions
May cause photosensitivity. Risk may be increased by concurrent therapy with known photosensitizers (thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides). Treatment can increase skin sensitivity to weather extremes of wind or cold. Also, concomitant topical medications (e.g. medicated or abrasive soaps, cleansers, or cosmetics with a strong drying effect) should be used with caution due to increased skin irritation. Potential teratogenicity. For external use only. Not for use on eczematous, broken, or sunburned skin. Not for treatment of lentigo maligna.