Thiamine (Vitamin B1)
- Atc Codes:A11DA01
- CAS Codes:67-03-8#59-43-8
- PHARMGKB ID:67-03-8#59-43-8
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Austria: Beneuran, Bevitol, Vit. B1; Belgium: Benerva, Betamine, Vitamine B1; Bulgaria: Vitamin B1; Finland: Neuramin; France: Benerva, Bevitine, Vitamine B1; Germany: Aneurin-AS, B1, Betabion, Novirell, Thiaminnitrat, Tolima, Vitamin B1; Greece: Benerva; Hungary: Vitamin B1; Italy: Benerva, VIT.B1; Latvia: Vitamin B1; Luxembourg: Benerva, Beneurol, Betamine; Netherlands: Thiamine; Poland: Vitaminum B1; Portugal: Tiamina; Romania: Sicovit B1; Slovakia: Thiamin; Spain: Benerva; Sweden: Benerva, Betabion; UK: Benerva.
North America
Canada: Betaxin; USA: Thiamine.
Latin America
Argentina: Tiamina; Brazil: Benerva, Beneum; Mexico: Benal, Benerva, MTX-2 ALF.
Asia
Japan: Abery, Actamin, Allynate F, Beeone, Berminbe, Biogen, B-Kapp, Dianoinamin, Glavitan, Hinonamin-F, Hithia, Metabolin, Mitan, Mututamin, Neodiamin-F, Plathiamin, Ronvelin, Thiadela, Vitanon.
Drug combinations
Thiamine: Acetaminophen; Ascorbic Acid (Vitamin C); Biotin (Vitamin B~7~); Caffeine; Calcium; Calcium Carbonate; Calcium Lactate; Calcium Phosphate, Tribasic; Cyproheptadine; Cysteine; Cholecalciferol; Cyanocobalamin (Vitamin B~12~); Dexamethasone, Dexpanthenol; Diclofenac; Ergocalciferol (Vitamin D~2~); Ferrous Fumarate; Ferrous Sulfate; Fluoride; Folic Acid (Vitamin B~9~); Ginkgo biloba; Ginseng; Hawthorn; Heparin; Hydroxocobalamin (Vitamin B~12a~), Lidocaine; Magnesium; Niacin (Vitamin B~3~); Niacinamide; Pantothenic Acid (Vitamin B~5~); Phytonadione (Vitamin K~1~); Procaine; Pyridoxine (Vitamin B~6~); Retinol (Vitamin A); Riboflavin (Vitamin B~2~); Tocopherol (Vitamin E)
Chemistry
Thiamine Hydrochloride: C~12~H~17~ClN~4~OS HCl. Mw: 337.27. (1) Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, chloride, monohydrochloride; (2) Thiamine monohydrochloride. CAS-67-03-8; CAS-59-43-8 (thiamine).
Pharmacologic Category
Vitamins; Vitamin B Complex. (ATC-Code: A11DA01).
Mechanism of action
An essential coenzyme in carbohydrate metabolism by combining with adenosine triphosphate to form thiamine pyrophosphate.
Therapeutic use
Treatment of thiamine deficiency including beriberi, Wernicke’s encephalopathy, Korsakoff’s syndrome, neuritis associated with pregnancy, or in alcoholic patients. Dietary supplement.
Pregnancy and lactiation implications
Thiamine requirements increased during pregnancy. Severe nausea and vomiting (hyperemesis gravidarum) may lead to thiamine deficiency manifested as Wernicke’s encephalopathy. Enters breast milk (use with caution in nursing women).
Unlabeled use
Contraindications
Hypersensitivity to thiamine or any component of the formulation.
Warnings and precautions
Hypersensitivity reactions reported following repeated parenteral doses. Administration of dextrose may precipitate acute symptoms of thiamine deficiency (use caution when thiamine status is marginal or suspect). Some parenteral products contain aluminum, (use caution in impaired renal function and neonates). Use with caution with parenteral route (especially I.V.) of administration.