Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Drug Interactions
  • Dosage

Brand Names

North America

USA: Evithrom, Recothrom, Thrombi, Thrombin.


Japan: Thrombin.

Drug combinations

Thrombin and Fibrinogen

Thrombin, Aprotinin, Calcium Chloride, and Fibrinogen

Thrombin, Aprotinin, Collagen, and Fibrinogen


Thrombin Alpha: C~1511~H~2342~N~418~O~436~S~15~. Mw: approx. 33820.01. (1) Thrombin (synthetic human); (2) Human thrombin (recombinant, glycosylated). CAS-869858-13-9 (2007).

Pharmacologic Category

Antihemorrhagic Agents; Hemostatics. (ATC-Code: B02BC06; B02BD30).

Mechanism of action

Activates platelets and catalyzes conversion of fibrinogen to fibrin, to promote hemostasis.

Therapeutic use

Hemostasis whenever minor bleeding from capillaries and small venules is accessible.

Pregnancy and lactiation implications

Unlabeled use


Hypersensitivity to thrombin or any component of the formulation. Not for direct injection into circulatory system (for topical use only).

Warnings and precautions

Bovine-source topical thrombin may be associated with abnormal hemostasis, ranging from asymptomatic laboratory alterations to severe bleeding and/or thrombosis. Abnormalities appear to be immunologically mediated. Repeated applications increase risk. Re-exposure of patients who develop antibodies to bovine thrombin preparations should be avoided. May potentially contain infectious agents which could transmit disease. Use caution in hypersensitivity to snake proteins (potential for allergic reaction). Do not use in infection. Use caution in areas of contamination. For topical use only. Do not inject intravenously or intra-arterially (intravascular clotting, possibly leading to death, may occur following injection). Powder and solution formulations may be used in combination with absorbable gelatin sponges.



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