Use in sulfonylurea allergy specifically contraindicated in product labeling, however, risk of cross-reaction exists in allergy to any of these compounds (avoid use when previous reaction severe). Nephrotoxicity might occur (oliguria, azotemia, and reversible increases in BUN and creatinine); fluid status and renal function should be monitored. Excess amounts can lead to profound diuresis with fluid and electrolyte loss (loop diuretics are potent diuretics). In cirrhosis, avoid electrolyte and acid/base imbalances which might lead to hepatic encephalopathy. Rapid I.V. administration, renal impairment, excessive doses, and concurrent use of other ototoxins associated with ototoxicity (seen with oral torsemide). Co-administration of antihypertensives may increase risk of hypotension.