Treprostinil
- Atc Codes:B01AC21
- CAS Codes:81846-19-7
- PHARMGKB ID:81846-19-7
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Remodulin; Cyprus: Remodulin; Czech Republic: Remodulin; Denmark: Remodulin; Estonia: Remodulin; Finland: Remodulin; France: Remodulin; Germany: Remodulin; Greece: Remodulin; Italy: Remodulin; Latvia: Remodulin; Lithuania: Remodulin; Netherlands: Remodulin; Poland: Remodulin; Portugal: Remodulin; Slovakia: Remodulin; Slovenia: Remodulin; Sweden: Remodulin.
North America
Canada: Remodulin; USA: Remodulin, Tyvaso.
Latin America
Argentina: Remodulin.
Drug combinations
Chemistry
Treprostinil: C~23~H~34~O~5~. Mw: 390.51. (1) Acetic acid, [[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-; (2) [(1R,2R,3aS,9aS)-2-Hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cylopent[b]naphthalen-5-yl]oxy]acetate. CAS-81846-19-7 (2002).
Pharmacologic Category
Vasodilating Agents, Miscellaneous. Prostacyclin. Prostaglandin. (ATC-Code: B01AC21).
Mechanism of action
A direct vasodilator of both pulmonary and systemic arterial vascular beds. Also inhibits platelet aggregation.
Therapeutic use
Treatment of pulmonary arterial hypertension.
Pregnancy and lactiation implications
Some skeletal malformations and maternal toxicity noted in animal studies. Use with caution in pregnancy and only if clearly needed. Excretion in breast milk unknown (use with caution in nursing women).
Unlabeled use
Contraindications
Warnings and precautions
Abrupt withdrawal or large dosage reductions may worsen symptoms of pulmonary arterial hypertension. Use with caution in hepatic and renal impairment. Chronic continuous I.V. infusion of treprostinil via chronic indwelling central venous catheter associated with serious bloodstream infections.