Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Substrate of
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Remodulin; Cyprus: Remodulin; Czech Republic: Remodulin; Denmark: Remodulin; Estonia: Remodulin; Finland: Remodulin; France: Remodulin; Germany: Remodulin; Greece: Remodulin; Italy: Remodulin; Latvia: Remodulin; Lithuania: Remodulin; Netherlands: Remodulin; Poland: Remodulin; Portugal: Remodulin; Slovakia: Remodulin; Slovenia: Remodulin; Sweden: Remodulin.

North America

Canada: Remodulin; USA: Remodulin, Tyvaso.

Latin America

Argentina: Remodulin.

Drug combinations


Treprostinil: C~23~H~34~O~5~. Mw: 390.51. (1) Acetic acid, [[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-; (2) [(1R,2R,3aS,9aS)-2-Hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cylopent[b]naphthalen-5-yl]oxy]acetate. CAS-81846-19-7 (2002).

Pharmacologic Category

Vasodilating Agents, Miscellaneous. Prostacyclin. Prostaglandin. (ATC-Code: B01AC21).

Mechanism of action

A direct vasodilator of both pulmonary and systemic arterial vascular beds. Also inhibits platelet aggregation.

Therapeutic use

Treatment of pulmonary arterial hypertension.

Pregnancy and lactiation implications

Some skeletal malformations and maternal toxicity noted in animal studies. Use with caution in pregnancy and only if clearly needed. Excretion in breast milk unknown (use with caution in nursing women).

Unlabeled use


Warnings and precautions

Abrupt withdrawal or large dosage reductions may worsen symptoms of pulmonary arterial hypertension. Use with caution in hepatic and renal impairment. Chronic continuous I.V. infusion of treprostinil via chronic indwelling central venous catheter associated with serious bloodstream infections.



Legal Notice
Privacy Policy
Cookie Policy


Phone: +34-981-780505
Location: Sta Marta de, C. P. Babío, S/N, 15165 Bergondo, A Coruña

Copyright © 2023 WAGEM

Add to cart