Triamterene
- Atc Codes:C03DB02
- CAS Codes:396-01-0
- PHARMGKB ID:396-01-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Genes that may be involved
- Substrate of
- Induces
- Nutrition/Nutraceutical Interactions
- Dosage
- Special Considerations
Brand Names
Europe
Belgium: Dytac; Ireland: Dyazide; Poland: Triamteren; UK: Dytac.
North America
USA: Dyrenium.
Asia
Japan: Diuteren, Triamterene, Triteren.
Drug combinations
Triamterene and Bemetizide
Triamterene and Epithiazide
Triamterene and Furosemide
Triamterene and Hydrochlorothiazide
Triamterene and Methyclothiazide
Triamterene and Trichlormethiazide
Triamterene and Xipamide
Triamterene, Hydrochlorothiazide, and Propranolol
Triamterene, Hydrochlorothiazide, and Verapamil
Chemistry
Triamterene: C~12~H~11~N~7~. Mw: 253.26. (1) 2,4,7-Pteridinetriamine, 6-phenyl-; (2) 2,4,7-Triamino-6-phenylpteridine. CAS-396-01-0 (1963).
Pharmacologic Category
Potassium-sparing Diuretics. (ATC-Code: C03DB02).
Mechanism of action
Interferes with potassium/sodium exchange (active transport) in distal tubule, cortical collecting tubule and collecting duct by inhibiting sodium, potassium-ATPase. Decreases calcium excretion. Increases magnesium loss.
Therapeutic use
Alone or in combination with other diuretics in treatment of edema and hypertension. Decreases potassium excretion caused by kaliuretic diuretics.
Pregnancy and lactiation implications
Generally, use of diuretics during pregnancy is avoided due to risk of decreased placental perfusion. Excretion in breast milk unknown.
Unlabeled use
Contraindications
Hypersensitivity to triamterene or any component of the formulation. Patients receiving other potassium-sparing diuretics. Anuria. Severe hepatic disease. Hyperkalemia or history of hyperkalemia. Severe or progressive renal disease. Pregnancy.
Warnings and precautions
Use with caution in prediabetes or diabetes mellitus (may see change in glucose control). Triamterene can cause photosensitivity. Hyperkalemia can occur (patients at risk include those with renal impairment, diabetes, the elderly, and the severely ill). Use with caution in severe hepatic dysfunction. In cirrhosis, avoid electrolyte and acid/base imbalances which might lead to hepatic encephalopathy. Avoid potassium supplements, potassium-containing salt substitutes, diet rich in potassium, or other drugs which can cause hyperkalemia. Excess amounts can lead to profound diuresis with fluid and electrolyte loss. Use with caution in kidney stones.