Use caution in depression, particularly if suicidal risk may be present. Use of hypnotic/sedative agents for sleep associated with hypersensitivity reactions including anaphylaxis as well as angioedema. Use with caution in renal impairment. Paradoxical reactions, including hyperactive or aggressive behavior, reported with benzodiazepines, particularly in adolescent/pediatric or psychiatric patients. Use with caution in respiratory compromise, COPD or sleep apnea. Increased risk for hazardous sleep-related activities such as sleep-driving; cooking and eating food, and making phone calls while asleep also noted. Use with caution in history of drug abuse or acute alcoholism (potential for drug dependency exists). Tolerance, psychological and physical dependence may occur with prolonged use. Benzodiazepines associated with anterograde amnesia. Use with caution in hepatic impairment. May cause CNS depression. Use with caution in impaired gag reflux, and in patients receiving other CNS depressants or psychoactive medication (effects with other sedative drugs or ethanol may be potentiated), taking strong CYP3A4 inhibitors, moderate or strong CYP3A4 inducers and major CYP3A4 substrates. Use with caution in debilitated patients. Use with extreme caution in patients at risk of falls (benzodiazepines associated with falls and traumatic injury). Rebound or withdrawal symptoms may occur following abrupt discontinuation or large decreases in dose. Failure of sleep disturbance to resolve after 7-10 days may indicate psychiatric or medical illness.