Trientine
- Atc Codes:V03AB
- CAS Codes:38260-01-4#112-24-3
- PHARMGKB ID:38260-01-4#112-24-3
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Syprine.
Asia
Japan: Metalite.
Drug combinations
Chemistry
Trientine Hydrochloride: C~6~H~18~N~4~ 2HCl. Mw: 219.16. (1) 1,2-Ethanediamine, N,N’-bis(2-aminoethyl)-, dihydrochloride; (2) Triethylenetetramine dihydrochloride. CAS-38260-01-4; CAS-112-24-3 (trientine)(1984).
Pharmacologic Category
Heavy Metal Antagonists. Chelating Agent. (ATC-Code: V03AB).
Mechanism of action
An effective oral chelator of copper used to induce adequate cupriuresis.
Therapeutic use
Treatment of Wilson’s disease in patients intolerant to penicillamine.
Pregnancy and lactiation implications
Use with caution during pregnancy. Excretion in breast milk unknown (use caution in nursing women).
Unlabeled use
Contraindications
Hypersensitivity to trientine or any component of the formulation.
Warnings and precautions
May cause iron-deficiency anemia. Copper deficiency induced by treatment. May lead to hepatic iron overload and/or sideroblastic anemia. Neurologic worsening may occur with treatment initiation, less common than with penicillamine. Hypersensitivity not reported with use, however, industrial workers exposed to trientine for prolonged periods have reported asthma, bronchitis, and dermatitis.