Trifluridine
- Atc Codes:S01AD02
- CAS Codes:70-00-8
- PHARMGKB ID:70-00-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
France: Virophta; Germany: Triflumann; Greece: Thilol, Viromidin; Italy: Triherpine; Luxembourg: Bephen, Triflumann; Poland: Triherpine.
North America
Canada: Trifluridine, Viroptic; USA: Trifluridine, Viroptic.
Drug combinations
Chemistry
Trifluridine: C~10~H~11~F~3~N~2~O~5~. Mw: 296.20. (1) Thymidine, α,α,α-trifluoro-; (2) 2′-Deoxy-5-(trifluoromethyl)uridine. CAS-70-00-8 (1977).
Pharmacologic Category
EENT Preparation; Antivirals. Ophthalmic Antiviral Agent. (ATC-Code: S01AD02).
Mechanism of action
Interferes with viral replication by incorporating into viral DNA in place of thymidine, inhibiting thymidylate synthetase, resulting in formation of defective proteins.
Therapeutic use
Treatment of primary keratoconjunctivitis and recurrent epithelial keratitis caused by herpes simplex virus types I and II.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Hypersensitivity to trifluridine or any component of the formulation.
Warnings and precautions
Mild local irritation of conjunctiva and cornea may occur when instilled (usually transient effects).