May cause anhidrosis and hyperthermia, which may be severe (use with caution especially when administered concomitantly with other atropine-like drugs to chronically-ill patients, alcoholics, patients with CNS disease, or persons doing manual labor in a hot environment). When given in large doses or to susceptible patients, may cause weakness and inability to move particular muscle groups. Use with caution in tachycardia, cardiac arrhythmias, hypertension, or hypotension; also in obstructive disease of GI tract, in glaucoma, and in hepatic or renal impairment. Mental illness may exacerbate mental symptoms when used to treat extrapyramidal symptoms. Use with caution in prostatic hyperplasia and/or urinary stricture or retention. Does not relieve symptoms of tardive dyskinesia.