Trimebutine
- Atc Codes:A03AA05
- CAS Codes:39133-31-8
- PHARMGKB ID:39133-31-8
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Nutrition/Nutraceutical Interactions
- Dosage
Brand Names
Europe
France: Debricalm, Debridat, Transacalm, Trimebutine; Greece: Garapepsin, Ibutin; Italy: Debridat, Digerent; Poland: Debretin, Debridat, Tribux; Portugal: Debridat; Romania: Colobutine, Colperin, Debridat, Ibutin, Promebutin, Trimebutin; Spain: Polibutin.
North America
Canada: Modulon, Trimebutine.
Latin America
Argentina: Altrip, Biorgan, Colixane, Debridat, Eumotil, Fenatrop, Miopropan, Plidex, Trimebutina; Brazil: Digedrat; Mexico: Cineprac, Crismotil, Debridat, Dolbutin, Espabion, Kisxon, Libertrim, Muttifen, Prescol, Scitin.
Asia
Japan: Butikinon, Celvel, Cerekinon, Cerenamelin, Hamoniton, Liement, Mebucolon, Mebutit, Meptart, Movarol, Mustrick, Naruhiton, Nepten, Nichimalon, Pelkysil, Pilemain, Sakion, Salnatin, Selumito, Supeslone, Tefmetin, Trikinosin, Trishi, Ve-M, Youmetazine.
Drug combinations
Trimebutine and Diazepam
Trimebutine and Medazepam
Trimebutine and Ruscogenine
Trimebutine and Simethicone
Chemistry
Trimebutine: C~22~H~29~NO~5~. Mw: 387.47. β-(Dimethylamino)-β-ethylphenethyl alcohol 3,4,5-trimethoxybenzoate. CAS-39133-31-8.
Pharmacologic Category
Gastrointestinal Drugs; Prokinetic Agents; 5-HT~3~ Receptor Antagonist. (ATC-Code: A03AA05).
Mechanism of action
Spasmolytic agent with antiserotonergic activity and moderate opiate receptor affinity. Reduces abnormal motility. Does not alter normal GI motility.
Therapeutic use
Treatment and relief of symptoms associated with irritable bowel syndrome (spastic colon). In postoperative paralytic ileus in order to accelerate resumption of intestinal transit following abdominal surgery.
Pregnancy and lactiation implications
Use in pregnancy and lactation not recommended.
Unlabeled use
Contraindications
Hypersensitivity to trimebutine or any component of the formulation.
Warnings and precautions
May increase sedation from CNS depressants and/or ethanol. May cause drowsiness (use with caution in CNS depression).