Trimethobenzamide
- Atc Codes:A04A
- CAS Codes:554-92-7#138-56-7
- PHARMGKB ID:554-92-7#138-56-7
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Tigan, Trimethobenzamide.
Drug combinations
Chemistry
Trimethobenzamide Hydrochloride: C~21~H~28~N~2~O~5~. HCl. Mw: 424.92. (1) Benzamide, N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-, monohydrochloride; (2) N-[p-[2-(Dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide monohydrochloride. CAS-554-92-7; CAS-138-56-7 (trimethobenzamide).
Pharmacologic Category
Antiemetics; Antihistamines. Anticholinergic Agent. (ATC-Code: A04A).
Mechanism of action
Acts centrally to inhibit medullary chemoreceptor trigger zone by blocking emetic impulses to vomiting center.
Therapeutic use
Treatment of postoperative nausea and vomiting. Treatment of nausea associated with gastroenteritis.
Pregnancy and lactiation implications
Teratogenic effects not observed in animal studies. Safety and efficacy not established in pregnant patients. Trimethobenzamide has been used to treat nausea and vomiting of pregnancy. Excretion in breast milk unknown.
Unlabeled use
Contraindications
Hypersensitivity to trimethobenzamide or any component of the formulation. Injection contraindicated in children.
Warnings and precautions
Allergic-type skin reactions reported with use. Trimethobenzamide clearance is predominantly renal. Risk of CNS adverse effects may be increased in acute febrile illness, dehydration, electrolyte imbalance, encephalitis, and gastroenteritis. May cause CNS depression. Antiemetic effects may mask toxicity of other drugs or conditions. Use capsule formulation with caution in children. Antiemetics not recommended for uncomplicated vomiting in children. Use of injection contraindicated in children. May cause extrapyramidal symptoms which may be confused with CNS symptoms of primary disease responsible for emesis.