Tromethamine (Trometamol)

Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Germany: Tham; Greece: Tham, Tromethamine; Italy: Thamesol; Sweden: Tham.

North America

Canada: Tham; USA: Tham.

Drug combinations


Tromethamine: C~4~H~11~NO~3~. Mw: 121.14. 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-; CAS-77-86-1 (1962).

Pharmacologic Category

Electrolytic, Caloric, and Water Balance; Alkalinizing Agents. (ATC-Code: B05BB03; B05XX02).

Mechanism of action

Acts as proton acceptor, which combines with hydrogen ions, liberating bicarbonate buffer, to correct acidosis. Buffers both metabolic and respiratory acids, limiting carbon dioxide generation. Also an osmotic diuretic.

Therapeutic use

Correction of metabolic acidosis associated with cardiac bypass surgery or cardiac arrest. Correction of excess acidity of stored blood preserved with acid citrate dextrose. Indicated in infants needing alkalinization after receiving maximum sodium bicarbonate (8-10 mEq/kg/24 hours).

Pregnancy and lactiation implications

Animal studies not conducted. There are no adequate, well-controlled studies in pregnant women. Use only if potential benefit outweighs possible risk to fetus. Excretion in breast milk unknown (use with caution in nursing women).

Unlabeled use


Hypersensitivity to tromethamine or any component of the formulation. Uremia or anuria. Chronic respiratory acidosis (neonates). Salicylate intoxication (neonates).

Warnings and precautions

May cause hypoglycemia with extremely large doses. May cause respiratory depression. Use with caution in renal impairment. Drug should not be given for period of longer than 24 hours unless for life-threatening situation. Avoid extravasation (may cause tissue necrosis).



Legal Notice
Privacy Policy
Cookie Policy


Phone: +34-981-780505
Location: Sta Marta de, C. P. Babío, S/N, 15165 Bergondo, A Coruña

Copyright © 2023 WAGEM

Add to cart