Tromethamine (Trometamol)
- Atc Codes:B05BB03#B05XX02
- CAS Codes:77-86-1
- PHARMGKB ID:77-86-1
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Germany: Tham; Greece: Tham, Tromethamine; Italy: Thamesol; Sweden: Tham.
North America
Canada: Tham; USA: Tham.
Drug combinations
Chemistry
Tromethamine: C~4~H~11~NO~3~. Mw: 121.14. 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-; CAS-77-86-1 (1962).
Pharmacologic Category
Electrolytic, Caloric, and Water Balance; Alkalinizing Agents. (ATC-Code: B05BB03; B05XX02).
Mechanism of action
Acts as proton acceptor, which combines with hydrogen ions, liberating bicarbonate buffer, to correct acidosis. Buffers both metabolic and respiratory acids, limiting carbon dioxide generation. Also an osmotic diuretic.
Therapeutic use
Correction of metabolic acidosis associated with cardiac bypass surgery or cardiac arrest. Correction of excess acidity of stored blood preserved with acid citrate dextrose. Indicated in infants needing alkalinization after receiving maximum sodium bicarbonate (8-10 mEq/kg/24 hours).
Pregnancy and lactiation implications
Animal studies not conducted. There are no adequate, well-controlled studies in pregnant women. Use only if potential benefit outweighs possible risk to fetus. Excretion in breast milk unknown (use with caution in nursing women).
Unlabeled use
Contraindications
Hypersensitivity to tromethamine or any component of the formulation. Uremia or anuria. Chronic respiratory acidosis (neonates). Salicylate intoxication (neonates).
Warnings and precautions
May cause hypoglycemia with extremely large doses. May cause respiratory depression. Use with caution in renal impairment. Drug should not be given for period of longer than 24 hours unless for life-threatening situation. Avoid extravasation (may cause tissue necrosis).