Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Substrate of
  • Drug Interactions
  • Dosage

Brand Names


Estonia: Helicap, Helicobacter Test Infai, Pylobactell; Finland: Calmuril, Canoderm, Diabact, Fenuril, Helicobacter Test Infai; France: Helicobacter Test Infai, Heli Kit, Ubit; Germany: Balisa, Basodexan, Carbamid, Diabact, Elacutan, Eucerin, Harnstoffsalbe, Heli-Kit, HeliCap, Helico, Helicobacter Test Infai, Hyanit, Linola Urea, Nubral, Onychomal, Pylobactell, Ubit, Ureotop; Ireland: Aquadrate, Diabact, Eucerin, Exterol, Helicobacter Test Infai, Nutraplus, Pylobactell; Italy: Helicobacter Test Infai; Luxembourg: Calmurid, Helicobacter Test Infai, Onychomal; Netherlands: Calmurid, HeliCap, Helicobacter Test Infai, Helico State, Pylobactell; Poland: Elacutan, Pylobactell; Portugal: Calmurid, HeliCap, Helicobacter Test Infai, Helico-teste, Pylobactell, Ubit; Spain: Tau Kit; Sweden: Calmuril, HeliCap; UK: Exterol, Otex.

North America

Canada: Dermaflex, Urea.

Latin America

Argentina: Keratopic, Ureadín, Uremol, Xerobase, Yadid; Brazil: Ureadin; Mexico: Derma-Keri, Dermoplast-Remexa, Karmosan, Nutraplus, Uramol.


Japan: Acetylol, Kerabens, Keratinamin, Pastaron, Pylonic, Ubit, Urepearl, Urimox, Vegin, Widecall.

Drug combinations

Urea and Bifonazole

Urea and Citric Acid

Urea and Clotrimazole

Urea and Dithranol

Urea and Hydrocortisone

Urea, Allantoin, and Coal Tar

Urea, Dexpanthenol, and Tretinoin

Urea, Magnesium, and Silver

Urea, Cresol, Phenol, and Sodium

Other Urea combinations: Dexpanthenol; Ginkgo biloba; Pantothenic Acid (Vitamin B~5~); Salicylic Acid


Urea: CH~4~N~2~O. Mw: 60.06. Carbamide. CAS-57-13-6.

Pharmacologic Category

Skin and Mucous Membrane Agents; Keratolytic Agents; Osmotic Diuretics; Topical Skin Product. (ATC-Code: D02AE01).

Mechanism of action

Urea softens hyperkeratotic areas by dissolving intracellular matrix, resulting in loosening horny layer of skin, or softening and debridement of nail plate.

Therapeutic use

Keratolytic agent to soften nails or skin. Moisturizer for dry, rough skin.

Pregnancy and lactiation implications

Use caution during pregnancy or lactation.

Unlabeled use


Hypersensitivity to urea or any component of the formulation. Viral skin disease.

Warnings and precautions

Appropriate application: Urea should not be used near eyes. Use with caution if applied to face or broken or inflamed skin.



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