Urea
- Atc Codes:D02AE01
- CAS Codes:57-13-6
- PHARMGKB ID:57-13-6
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Drug Interactions
- Dosage
Brand Names
Europe
Estonia: Helicap, Helicobacter Test Infai, Pylobactell; Finland: Calmuril, Canoderm, Diabact, Fenuril, Helicobacter Test Infai; France: Helicobacter Test Infai, Heli Kit, Ubit; Germany: Balisa, Basodexan, Carbamid, Diabact, Elacutan, Eucerin, Harnstoffsalbe, Heli-Kit, HeliCap, Helico, Helicobacter Test Infai, Hyanit, Linola Urea, Nubral, Onychomal, Pylobactell, Ubit, Ureotop; Ireland: Aquadrate, Diabact, Eucerin, Exterol, Helicobacter Test Infai, Nutraplus, Pylobactell; Italy: Helicobacter Test Infai; Luxembourg: Calmurid, Helicobacter Test Infai, Onychomal; Netherlands: Calmurid, HeliCap, Helicobacter Test Infai, Helico State, Pylobactell; Poland: Elacutan, Pylobactell; Portugal: Calmurid, HeliCap, Helicobacter Test Infai, Helico-teste, Pylobactell, Ubit; Spain: Tau Kit; Sweden: Calmuril, HeliCap; UK: Exterol, Otex.
North America
Canada: Dermaflex, Urea.
Latin America
Argentina: Keratopic, Ureadín, Uremol, Xerobase, Yadid; Brazil: Ureadin; Mexico: Derma-Keri, Dermoplast-Remexa, Karmosan, Nutraplus, Uramol.
Asia
Japan: Acetylol, Kerabens, Keratinamin, Pastaron, Pylonic, Ubit, Urepearl, Urimox, Vegin, Widecall.
Drug combinations
Urea and Bifonazole
Urea and Citric Acid
Urea and Clotrimazole
Urea and Dithranol
Urea and Hydrocortisone
Urea, Allantoin, and Coal Tar
Urea, Dexpanthenol, and Tretinoin
Urea, Magnesium, and Silver
Urea, Cresol, Phenol, and Sodium
Other Urea combinations: Dexpanthenol; Ginkgo biloba; Pantothenic Acid (Vitamin B~5~); Salicylic Acid
Chemistry
Urea: CH~4~N~2~O. Mw: 60.06. Carbamide. CAS-57-13-6.
Pharmacologic Category
Skin and Mucous Membrane Agents; Keratolytic Agents; Osmotic Diuretics; Topical Skin Product. (ATC-Code: D02AE01).
Mechanism of action
Urea softens hyperkeratotic areas by dissolving intracellular matrix, resulting in loosening horny layer of skin, or softening and debridement of nail plate.
Therapeutic use
Keratolytic agent to soften nails or skin. Moisturizer for dry, rough skin.
Pregnancy and lactiation implications
Use caution during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to urea or any component of the formulation. Viral skin disease.
Warnings and precautions
Appropriate application: Urea should not be used near eyes. Use with caution if applied to face or broken or inflamed skin.