Gaucher’s disease is an autosomal recessive disorder caused by mutations in the GBA gene, which results in a deficiency of the lysosomal enzyme β-glucocerebrosidase. Glucocerebrosidase catalyzes the conversion of the sphingolipid glucocerebroside into glucose and ceramide. The enzymatic deficiency causes an accumulation of glucocerebroside primarily in the lysosomal compartment of macrophages, giving rise to foam cells or «Gaucher cells». In this lysosomal storage disorder (LSD), clinical features are reflective of the accumulation of Gaucher cells in the liver, spleen, bone marrow, and other organs. The accumulation of Gaucher cells in the liver and spleen leads to organomegaly. The presence of Gaucher cells in the bone marrow and spleen leads to clinically significant anemia and thrombocytopenia. Velaglucerase alpha catalyzes the hydrolysis of glucocerebroside, reducing the amount of accumulated glucocerebroside.