Xylometazoline
- Atc Codes:R01AA07#S01GA03
- CAS Codes:1218-35-5#526-36-3
- PHARMGKB ID:1218-35-5#526-36-3
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Special Considerations
Brand Names
Europe
Austria: Otrivin, Ratiosoft, Xylo-Comod; Belgium: Nasa Rhinathiol, Nasasinutab, Nuso-San, Otrivine, Xylometazoline; Bulgaria: Grippostad-Rhino, Nasan, Olynth, Xylogel, Xylometazoline, Xylopharm, Xylorhin; Czech Republic: Mar Rhino, Nasenspray, Nasentropfen, Nasic, Olynth, Otrivin, Rinoxyl, Xylo-Comod; Denmark: Klarigen-Copyfarm, Otrivin, Zymelin; Estonia: Galazolin, Otrivin, Sudafed Xylo, Xylo-Mepha, Xymelin; Finland: Nasolin, Otrivin; Germany: Balkis, Brufasol, Docpelin Nasenspray, Dorenasin, Gelonasal, Imidin, Nasan, Nasentropfen, Olynth, Otriven, Rapako, Schnupfen, Siozwo Nasengel, Snup Schnupfenspray, Tussamag Nasenspray, Vitanasin, Werozolin, Xylo-Comod, Xylometazolin; Greece: Otrivin; Ireland: Otrivine, Non-Drowsy Sudafed Decongestant Nasal Spray; Italy: Otrivin; Luxembourg: Balkis, Nasan, NasenGel, NasenSpray, NasenTropfen, Otrivine, Rhinidine; Netherlands: Neusdruppels, Otrivin, Xylometazoline; Poland: Donosan, Otrivin, Xylogel, Xylometazolin, Xylorhin; Portugal: Otrivina, Rinorex; Romania: Bixtonim, Olynth, Otrinase, Rhinxyl, Xylo; Spain: Amidrín, Idasal, Otrivín, Rinoblanco; Sweden: Nasoferm, Noxorin, Otrivin, Zymelin; UK: Otrivine, Non-Drowsy Sudafed Decongestant Nasal Spray.
North America
Canada: Balminil Decongest, Decongest Nasal, Otrivin, Vaporisateur Nasal.
Latin America
Argentina: Otrivina, Xylometazolina; Brazil: Otrivina.
Drug combinations
Xylometazoline and Dexpanthenol
Xylometazoline and Ipratropium
Other Xylometazoline combinations: Pantothenic Acid (Vitamin B~5~)
Chemistry
Xylometazoline Hydrochloride: C~16~H~24~N~2~ HCl. Mw: 280.84. (1) 1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, monohydrochloride; (2) 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline monohydrochloride. CAS-1218-35-5; CAS-526-36-3 (xylometazoline).
Pharmacologic Category
EENT Preparations; Vasoconstrictors. Imidazoline Derivative. Nasal Vasoconstrictor. (ATC-Code: R01AA07; S01GA03).
Mechanism of action
Stimulates α-adrenergic receptors in arterioles of conjunctiva and nasal mucosa to produce vasoconstriction.
Therapeutic use
Symptomatic relief of nasal and nasopharyngeal mucosal congestion.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Warnings and precautions
Excessive use may cause rebound congestion or chemical rhinitis. Use with caution in hypertension, diabetes, cardiovascular or coronary artery disease, hyperthyroidism, long-standing bronchial asthma.