Nafcillin
- Atc Codes:J01CF
- CAS Codes:7177-50-6#985-16-0#147-52-4
- PHARMGKB ID:7177-50-6#985-16-0#147-52-4
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Induces
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Nafcillin.
Drug combinations
Chemistry
Nafcillin Sodium: C~21~H~21~N~2~NaO~5~S H~2~O. Mw: 454.47. (1) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6β)]; (2) Monosodium (2S,5R,6R)-6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrate. CAS-7177-50-6; CAS-985-16-0 (anhydrous); CAS-147-52-4 (nafcillin)(1963).
Pharmacologic Category
Antibacterials; Penicillinase-resistant Penicillins. (ATC-Code: J01CF).
Mechanism of action
Interferes with bacterial cell wall synthesis during active multiplication, causing cell wall death and resultant bactericidal activity against susceptible bacteria.
Therapeutic use
Treatment of infections such as osteomyelitis, septicemia, endocarditis, and CNS infections caused by susceptible strains of staphylococci species.
Pregnancy and lactiation implications
Adverse events not observed in animal studies. Human experience with penicillins during pregnancy has not shown any positive evidence of adverse effects on fetus. Enters breast milk (use caution).
Unlabeled use
Contraindications
Hypersensitivity to nafcillin, or any component of the formulation, or penicillins.
Warnings and precautions
Serious and occasionally severe or fatal hypersensitivity (anaphylactoid) reactions reported in patients on penicillin therapy, especially with history of β-lactam hypersensitivity, sensitivity to multiple allergens, or previous IgE-mediated reactions (e.g. anaphylaxis, angioedema, urticaria). Use with caution in asthmatic patients. Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Use with caution in severe hepatic and renal impairment, in neonates (slow drug elimination). Avoid extravasation of I.V. infusions. Penicillins reported to cause apprehension, illusions, hallucinations, depersonalization, agitation, insomnia, and encephalopathy.