Carbachol
- Atc Codes:N07AB01#S01EB02
- CAS Codes:51-83-2
- PHARMGKB ID:51-83-2
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Dosage
Brand Names
Europe
Belgium: Miostat; Czech Republic: Miostat; France: Miostat; Germany: Carbamann, Isopto-Carbachol; Greece: Miostat; Hungary: Miostat; Luxembourg: Isopto Carbachol, Miostat; Netherlands: Miostat; Poland: Carbachol, Isopto Carbachol, Miostat; Romania: Miostat; Slovenia: Miostat; Sweden: Isopto Karbakolin, Miostat.
North America
Canada: Isopto Carbachol, Miostat; USA: Carbachol, Miostat.
Asia
Japan: Miostat.
Drug combinations
Chemistry
Carbachol: C~6~H~15~ClN~2~O~2~. Mw: 182.65. (1) Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride; (2) Choline chloride, carbamate. CAS-51-83-2.
Pharmacologic Category
Antiglaucoma Agents; Miotics. (ATC-Code: N07AB01; S01EB02).
Mechanism of action
Synthetic direct-acting cholinergic agent that causes miosis by stimulating muscarinic receptors in the eye.
Therapeutic use
To lower intraocular pressure in the treatment of glaucoma. To produce miosis during surgery.
Pregnancy and lactiation implications
No adequate studies conducted in pregnant women. Use with caution during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to carbachol or any component of the formulation. Acute iritis, acute inflammatory disease of the anterior chamber.
Warnings and precautions
It is suggested that intraocular carbachol does not produce the adverse effects of topically applied carbachol. Corneal clouding, persistent bullous keratopathy, retinal detachment and postoperative iritis following cataract extraction reported. Use with caution in asthma, in the presence of corneal abrasion, in peptic ulcer disease or gastrointestinal spasm, in acute heart failure, in hyperthyroidism, in Parkinson’s disease, in urinary tract obstruction, or in patients undergoing general anesthesia.