Protease inhibitors have been associated with a variety of hypersensitivity events (some severe), including rash, anaphylaxis (rare), angioedema, bronchospasm, erythema multiforme, and/or Stevens-Johnson syndrome (rare). Patients may develop immune reconstitution syndrome. Increases in total cholesterol and triglycerides reported. Use with caution in sulfonamide allergy. Hyperglycemia, exacerbation of diabetes, DKA, and new-onset diabetes mellitus reported in patients receiving protease inhibitors. Use with caution in hemophilia A or B, and in underlying hepatic disease, such as hepatitis B or C or cirrhosis. Potential for CYP-mediated interactions. Avoid use with hormonal contraceptives (e.g. ethinyl estradiol/norethindrone). Estrogen/progestin levels may be reduced with concomitant use. May cause fat redistribution. Acute hemolytic anemia reported.