Spiramycin
- Atc Codes:J01FA02
- CAS Codes:8025-81-8
- PHARMGKB ID:8025-81-8
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Substrate of
- Inhibits
- Induces
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Austria: Rovamycin; Belgium: Rovamycine; Bulgaria: Rovamycine; Czech Republic: Rovamycine; Estonia: Rovamycine; France: Rovamycine, Spiramycine; Germany: Rovamycine, Selectomycin; Greece: Rovalen, Rovamycine; Hungary: Rovamycine; Italy: Rovamicina, Spiramicina, Spiromix; Latvia: Rovamycine; Lithuania: Rovamycine; Luxembourg: Rovamycine; Netherlands: Rovamycine; Poland: Rovamycine; Portugal: Rovamycine; Romania: Rovamycine; Slovakia: Rovamycine; Spain: Rovamycine.
North America
Canada: Rovamycine.
Latin America
Argentina: Rovamycine; Brazil: Rovamicina; Mexico: Provamicina.
Drug combinations
Spiramycin and Metronidazole
Chemistry
Spiramycin: C~43~H~74~N~2~O~14~. Mw: 843.05. Antibiotic produced by Streptomyces ambofaciens. Leucomycin. CAS-8025-81-8 (1962).
Pharmacologic Category
Antibacterials; Other Macrolides. (ATC-Code: J01FA02).
Mechanism of action
Inhibits growth of susceptible organisms. Mechanism unknown.
Therapeutic use
Infections of respiratory tract, buccal cavity, skin and soft tissues due to susceptible organisms. Alternate choice of treatment for gonorrhea in allergy to penicillins.
Pregnancy and lactiation implications
Crosses placenta. Specific safety information not available. However, spiramycin has been used to treat T. gondii to prevent transmission from mother to fetus. Enters breast milk (compatible with lactation).
Unlabeled use
Toxoplasma gondii to prevent transmission from mother to fetus.
Contraindications
Hypersensitivity to spiramycin, other macrolides (e.g. erythromycin) or any component of the formulation.
Warnings and precautions
Macrolides associated with rare QTc prolongation and ventricular arrhythmias, including torsade de pointes (use with caution in risk of prolonged cardiac repolarization). Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Use with caution in pre-existing liver disease (hepatic impairment, including hepatocellular and/or cholestatic hepatitis, with or without jaundice observed).