Hypocalcemia, hypokalemia, and hypomagnesemia reported. Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Nephrotoxicity and ototoxicity are the most serious adverse effects (are most likely to occur in renal impairment, in geriatric patients, and in patients who are receiving other nephrotoxic and/or ototoxic drugs). Extreme caution if used in pre-existing auditory or renal impairment. Use with nonantituberculous drugs (i.e. aminoglycoside antibiotics) having ototoxic or nephrotoxic potential should be undertaken only with great caution. Simultaneous administration of parenteral antituberculous agents (e.g. streptomycin) with capreomycin is not recommended (have similar and sometimes irreversible toxic effects, particularly on eighth cranial nerve and renal function). Use with caution in the elderly.