Natamycin
- Atc Codes:A01AB10#A07AA03#D01AA02#G01AA02#S01AA10
- CAS Codes:7681-93-8
- PHARMGKB ID:7681-93-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Germany: Pima Biciron N; Greece: Natacyn; Poland: Natacyn, Natamycyna.
North America
USA: Natacyn.
Latin America
Argentina: Natacyn; Mexico: Miconacina.
Asia
Japan: Pimaricin.
Drug combinations
Chemistry
Natamycin: C~33~H~47~NO~13~. Mw: 665.73. (1) Pimaricin; (2) Stereoisomer of 22-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0^5,7^]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid. CAS-7681-93-8 (1977).
Pharmacologic Category
EENT Preparations; Antifungals. Ophthalmic Antifungal Agent. (ATC-Code: A01AB10; A07AA03; D01AA02; G01AA02; S01AA10).
Mechanism of action
Increases cell membrane permeability in susceptible fungi.
Therapeutic use
Treatment of blepharitis, conjunctivitis, and keratitis caused by susceptible fungi (Aspergillus, Candida, Cephalosporium, Curvularia, Fusarium, Penicillium, Microsporum, Epidermophyton, Blastomyces dermatitidis, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Sporothrix schenckii, and Trichomonas vaginalis).
Pregnancy and lactiation implications
Use caution in pregnant and nursing women.
Unlabeled use
Contraindications
Hypersensitivity to natamycin or any component of the formulation.
Warnings and precautions
For topical eye use only. Failure to improve (keratitis) after 7-10 days of administration suggests infection caused by microorganism not susceptible to natamycin. Inadequate as single agent in fungal endophthalmitis. Suspension may adhere to epithelial ulcers.