Cyproterone
- Atc Codes:G03HA01
- CAS Codes:427-51-0#2098-66-0
- PHARMGKB ID:427-51-0#2098-66-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Andro-Diane, Androcur, MaskuPel; Belgium: Androcur, Cyproplex; Bulgaria: Androcur, Cyproterone; Czech Republic: Androcur, Cyproplex, Cyproteronacetat, Cysaxal; Denmark: Androcur; Estonia: Androcur; Finland: Androcur; France: Androcur, Cyproterone; Germany: Androcur, Cyproteron, Virilit; Greece: Androcur, Cyproterone; Hungary: Androcur, Cysaxal; Ireland: Androcur; Italy: Androcur; Latvia: Androcur, Cyproplex; Lithuania: Androcur, Cyproplex; Netherlands: Androcur, Cyproteronacetaat, Cysaxal; Poland: Androcur; Portugal: Androcur, Ciproterona; Romania: Androcur; Slovakia: Androcur, Cyproplex; Slovenia: Androcur; Spain: Androcur; Sweden: Androcur; UK: Androcur, Cyprostat, Cyproterone.
North America
Canada: Androcur, Cyproterone.
Latin America
Argentina: Androcur, Androstat, Asoteron, Ceprater, Ciclamil, Ciprofarma, Ciproplex, Ciproterona, Kebirterona, Omnigeriat, Purfilx; Brazil: Andelux, Androcur, Androneo, Androsteron, Cetoteron, Ciprostat, Tess; Mexico: Androcur, Bagopront, Neoproxil.
Drug combinations
Cyproterone and Estradiol
Cyproterone and Ethinyl Estradiol
Chemistry
Cyproterone Acetate: C~24~H~29~ClO~4~. Mw: 416.94. (1) 3’H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1β,2β)-; (2) 6-Chloro-1β,2β-dihydro-17-hydroxy-3’H-cyclopropa[1,2]-pregna-1,4,6-triene-3,20-dione acetate. CAS-427-51-0; CAS-2098-66-0 (cyproterone)(1965).
Pharmacologic Category
Hormones and Synthetic Substitutes; Antiandrogens. (ATC-Code: G03HA01).
Mechanism of action
Cyproterone is a steroidal compound with antiandrogenic, antigonadotropic, and progestin-like activity.
Therapeutic use
Palliative treatment of advanced prostate carcinoma.
Pregnancy and lactiation implications
Not indicated for use in women.
Unlabeled use
Contraindications
Hypersensitivity to cyproterone or any component of the formulation. Active liver disease or hepatic dysfunction. Renal impairment.
Warnings and precautions
Has been associated with hepatic toxicity (jaundice, hepatitis, hepatic failure; toxicity develops after several months of therapy). May increase HDL-C and decrease LDL-C. Triglycerides may also be increased (use with caution in familial defects of lipoprotein metabolism). May increase the risk of thromboembolism. Use with caution in conditions which may be aggravated by fluid retention, or cardiovascular disease. Has been associated with an increased incidence of depression. May cause alterations in glucose metabolism (caution if diabetes or impaired glucose tolerance).