Dexchlorpheniramine
- Atc Codes:R06AB02
- CAS Codes:2438-32-6#25523-97-1
- PHARMGKB ID:2438-32-6#25523-97-1
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Belgium: Polaramine; Denmark: Polaramin; France: Polaramine; Italy: Polaramin; Luxembourg: Polaramine; Netherlands: Polaramine; Portugal: Trenelone; Spain: Polaramine; Sweden: Polaramin.
North America
USA: Dexchlorpheniramine.
Latin America
Argentina: Afeme; Brazil: Alergonil, Dexclorfeniramina, Histamin, Hystin, Polaratin, Polaren, Polaryn.
Drug combinations
Dexchlorpheniramine and Betamethasone
Dexchlorpheniramine and Pseudoephedrine
Chemistry
Dexchlorpheniramine Maleate: C~16~H~19~ClN~2~ C~4~H~4~O~4~. Mw: 390.86. (1) 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (S)-, (Z)-2-butenedioate (1:1); (2)(+)-2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine maleate (1:1). CAS-2438-32-6; CAS-25523-97-1 (dexchlorpheniramine).
Pharmacologic Category
First Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AB02).
Mechanism of action
Competes with histamine for H~1~-receptor sites on effector cells in the GI tract, blood vessels, and respiratory tract.
Therapeutic use
Perennial and seasonal allergic rhinitis and other allergic symptoms including urticaria.
Pregnancy and lactiation implications
Breast-feeding is not recommended during treatment.
Unlabeled use
Contraindications
Hypersensitivity to dexchlorpheniramine or any component of the formulation. Narrow-angle glaucoma.
Warnings and precautions
May cause CNS depression. Effects may be potentiated when used with other sedative drugs or ethanol. Caution in cardiovascular disease, increased intraocular pressure, prostatic hyperplasia and/or genitourinary obstruction, pyloroduodenal obstruction or thyroid dysfunction. May cause excitation in young children.