Fluoxymesterone
- Atc Codes:G03BA01
- CAS Codes:76-43-7
- PHARMGKB ID:76-43-7
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Fluoxymesterone.
Latin America
Mexico: Stenox.
Asia
Japan: Halotestin.
Drug combinations
Chemistry
Fluoxymesterone: C~20~H~29~FO~3~. Mw: 336.44. (1) Androst-4-en-3-one, 9-fluoro-11,17-dihydroxy-17-methyl-, (11β,17β)-; (2) 9-Fluoro-11β,17β-dihydroxy-17-methylandrost-4-en-3-one. CAS-76-43-7.
Pharmacologic Category
Hormones and Synthetic Substitutes; Androgens. (ATC-Code: G03BA01).
Mechanism of action
Synthetic androgenic anabolic hormone responsible for normal growth and development of male sex hormones and development of male sex organs and maintenance of secondary sex characteristics. Synthetic testosterone derivative with significant androgen activity. Stimulates RNA polymerase activity resulting in increase in protein production. Increases bone development.
Therapeutic use
Replacement of endogenous testicular hormone. In females, palliative treatment of breast cancer.
Pregnancy and lactiation implications
Contraindicated in pregnancy (may cause fetal harm).
Unlabeled use
Stimulation of erythropoiesis, angioneurotic edema.
Contraindications
Hypersensitivity to fluoxymesterone or any component of the formulation. Serious cardiac disease. Liver or kidney disease. Pregnancy.
Warnings and precautions
Hepatic effects may occur with prolonged use and/or high doses (i.e. peliosis hepatis, liver cell tumors, cholestatic hepatitis with jaundice or abnormal liver function tests). Use with caution in breast cancer (may cause hypercalcemia by stimulating osteolysis), diabetes mellitus, in edematous conditions (may cause fluid retention), hepatic impairment, or in elderly patients (might be at greater risk for prostatic hyperplasia, fluid retention, and transaminase elevations). May accelerate bone maturation without producing compensatory gain in linear growth in children. May cause mild virilization in women. Product may contain tartrazine.