Amantadine
- Atc Codes:N04BB01
- CAS Codes:665-66-7#768-94-5
- PHARMGKB ID:665-66-7#768-94-5
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Amantadinsulfat, Hofcomant, PK-Merz; Belgium: Amantan; Bulgaria: PK-Merz, Viregyt; Cyprus: Symmetrel; Czech Republic: PK-Merz, Viregyt; Estonia: Amantadin, PK-Merz; Finland: Atarin; France: Mantadix; Germany: Adekin, Amantadin, Amantagamma, Amixx, PK-Merz, Tregor; Greece: Hofcomant, Symmetrel; Hungary: PK-Merz, Viregyt; Italy: Mantadan; Latvia: Neomidantan, PK-Merz; Lithuania: Amantadin, PK-Merz; Luxembourg: Amantan, Mantadix, PK-Merz; Malta: PK-Merz; Netherlands: Symmetrel; Poland: Amantadin, Amantix, Viregyt; Portugal: PK-Merz, Parkadina; Romania: Viregyt; Slovakia: PK-Merz, Viregyt; Spain: Amantadine; UK: Symmetrel.
North America
Canada: Amantadine; USA: Amantadine, Symmetrel.
Latin America
Argentina: Actisón, Ampakine, Virosol; Brazil: Mantidan; Mexico: Kinestrel, PK-Merz.
Asia
Japan: Amantadine, Amazolon, Atenegine, Boidan, Granzart, Lusyton, Rotifamin, Shikitan, Symmetrel, Topharmin.
Drug combinations
Amantadine, Acetaminophen, and Chlorpheniramine
Amantadine, Acetaminophen, and Phenylephrine
Chemistry
Amantadine Hydrochloride: C~10~H~17~N HCl. Mw: 187.71. (1) Tricyclo[3.3.1.1^3,7^]decan-1-amine, hydrochloride. CAS-665-66-7; CAS-768-94-5 (amantadine)(1964).
Pharmacologic Category
Antiparkinsonian Agents, Adamantanes; Dopamine Agonists. (ATC-Code: N04BB01).
Mechanism of action
Antiparkinsonian activity may be due to inhibition of dopamine reuptake into presynaptic neurons or by increasing dopamine release from presynaptic fibers.
Therapeutic use
Treatment of parkinsonism, or drug-induced extrapyramidal symptoms.
Pregnancy and lactiation implications
Teratogenic effects were observed in animal studies. Impaired fertility has also been reported during animal studies and during human in vitro fertilization. Administration during lactation is not recommended.
Unlabeled use
Contraindications
Hypersensitivity to amantadine, rimantadine, or any component of the formulation.
Warnings and precautions
May cause CNS depression. Neuroleptic malignant syndrome may occur (associated with dose reduction or abrupt discontinuation). Dopamine agonists used for Parkinson’s disease or restless legs syndrome have been associated with compulsive behaviors and/or loss of impulse control (causality not yet established). Suicidal ideation reported (may exacerbate mental problems in patients with history of mental illness). Caution in heart failure, peripheral edema, or orthostatic hypotension, eczema, hepatic impairment, renal impairment, seizure disorder, or in the elderly. Avoid use in untreated glaucoma. Use with caution in uncontrolled psychosis or severe psychoneurosis and in patients receiving CNS stimulant drugs. Do not discontinue abruptly when treating Parkinson’s disease.