Aminosalicylic Acid
- Atc Codes:J04AA01
- CAS Codes:65-49-6#6018-19-5#133-10-8
- PHARMGKB ID:65-49-6#6018-19-5#133-10-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Paser.
Drug combinations
Chemistry
Aminosalicylic Acid: C~7~H~7~NO~3~. Mw: 153.14. Benzoic acid, 4-amino-2-hydroxy-. CAS-65-49-6.
Aminosalicylate Sodium: C~7~H~6~NNaO~3~ 2H~2~O. Mw: 211.15. Monosodium 4-aminosalicylate dihydrate. CAS-6018-19-5; CAS-133-10-8 (anhydrous).
Pharmacologic Category
Antituberculosis Agents; Salicylate. (ATC-Code: J04AA01).
Mechanism of action
Competitive antagonism with para-aminobenzoic acid (PABA). Disrupts plate biosynthesis in sensitive organisms.
Therapeutic use
Adjunctive treatment of tuberculosis.
Pregnancy and lactiation implications
Use during pregnancy only if clearly needed. Not recommended during lactation.
Unlabeled use
Crohn’s disease.
Contraindications
Hypersensitivity to aminosalicylic acid or any component of the formulation.
Warnings and precautions
Increased risk of salicylate sensitivity in patients with sensitivity to tartrazine dyes, nasal polyps, or asthma. Use with caution in gastric ulcer, hepatic or renal impairment.