Anidulafungin
- Atc Codes:J02AX06
- CAS Codes:166663-25-8
- PHARMGKB ID:166663-25-8
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Ecalta; Belgium: Ecalta; Bulgaria: Ecalta; Cyprus: Ecalta, Czech Republic: Ecalta; Denmark: Ecalta; Estonia: Ecalta; Finland: Ecalta; France: Ecalta; Germany: Ecalta; Greece: Ecalta; Hungary: Ecalta; Ireland: Ecalta; Italy: Ecalta; Latvia: Ecalta; Lithuania: Ecalta; Malta: Ecalta; Netherlands: Ecalta; Poland: Ecalta; Portugal: Ecalta; Romania: Ecalta; Slovakia: Ecalta; Slovenia: Ecalta; Spain: Ecalta; Sweden: Ecalta; UK: Ecalta.
North America
Canada: Eraxis; USA: Eraxis.
Latin America
Argentina: Ecalta.
Drug combinations
Chemistry
Anidulafungin: C~58~H~73~N~7~O~17~. Mw: 1140.24. (1) Echinocandin B, 1-[(4R,5R)-4,5-dihydroxy-N^2^-[[4»-(pentyloxy)[1,1′:4′,1»-terphenyl]-4-yl]carbonyl]-L-ornithine]-; (2)(4R,5R)-4,5-Dihydroxy-N^2^-[[4»-(pentyloxy)-p-terphenyl-4-yl]carbonyl]-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-L-threonyl-(3S,4S)-3-hydroxy-4-methyl-L-proline cyclic (6→1)-peptide. CAS-166663-25-8 (1998).
Pharmacologic Category
Antifungals; Echinocandins. (ATC-Code: J02AX06).
Mechanism of action
Decreases glucan content in Candida leading to osmotic instability and cellular lysis.
Therapeutic use
Treatment of candidemia and other forms of Candida infection (intra-abdominal, peritoneal, and esophageal locus).
Pregnancy and lactiation implications
There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Use with caution during lactation.
Unlabeled use
Treatment of Aspergillus spp. infections.
Contraindications
Hypersensitivity to anidulafungin, other echinocandins, or any component of the formulation.
Warnings and precautions
Hepatic effects reported (elevated liver function tests, hepatitis, and worsening hepatic failure). Histamine-mediated reactions (e.g. urticaria, flushing, hypotension) observed.