May inhibit electron transport in mitochondria inhibiting metabolic enzymes.
Therapeutic use
Treatment and profilaxis of Pneumocystis carinii pneumonia in intolerance to co-trimoxazole. Treatment of Toxoplasma gondii encephalitis. Primary prophylaxis of HIV-infected persons at high risk for developing Toxoplasma gondii encephalitis.
Pregnancy and lactiation implications
Use during pregnancy only if potential benefit outweighs possible risk to the fetus. Caution during lactation.
Unlabeled use
Contraindications
Life-threatening allergic reaction to the drug or formulation.
Warnings and precautions
Absorption may be decreased in diarrhea or vomiting. Use with caution in severe hepatic impairment or in elderly patients (potentially impaired renal, hepatic, and cardiac function).