Aztreonam
- Atc Codes:J01DF01
- CAS Codes:78110-38-0
- PHARMGKB ID:78110-38-0
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Azactam; Belgium: Azactam; Bulgaria: Azactam; Czech Republic: Cayston; Denmark: Azactam; Estonia: Cayston; Finland: Azactam; France: Azactam; Germany: Azactam; Greece: Azactam; Ireland: Azactam, Cayston; Italy: Primbactam; Latvia: Cayston; Malta: Azactam; Netherlands: Cayston; Portugal: Azactam; Slovakia: Azactam; Spain: Azactam; Sweden: Azactam, Cayston; UK: Cayston.
North America
Canada: Cayston; USA: Azactam, Cayston.
Latin America
Argentina: Aztreonam; Brazil: Azactam, Aztreonam; Mexico: Monobac.
Asia
Japan: Azactam.
Drug combinations
Chemistry
Aztreonam: C~13~H~17~N~5~O~8~S~2~. Mw: 435.43. (1) Propanoic acid, 2-[[[1-(2-amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methyl-, [2S-[2α,3β(Z)]]-; (2)(Z)-2-[[[(2-Amino-4-thiazolyl)[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]carbamoyl]methylene]amino]oxy]-2-methylpropionic acid. CAS-78110-38-0 (1983).
Pharmacologic Category
Antibacterials; Miscellaneous β-Lactams; Monobactams. (ATC-Code: J01DF01).
Mechanism of action
Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls.
Therapeutic use
Susceptible Gram-negative bacilli infections (urinary tract, lower respiratory tract, septicemia, skin/skin structure, intra-abdominal, gynecological).
Pregnancy and lactiation implications
Aztreonam crosses the placenta. Distribution to the fetus is minimal in early pregnancy. Aztreonam is used therapeutically in newborns. Not recommended during lactation.
Unlabeled use
Contraindications
Hypersensitivity to aztreonam or any component of the formulation.
Warnings and precautions
Cross-allergenicity to penicillins and cephalosporins may occur. Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Use with caution in renal impairment.