Use with caution in previous sensitivity to acetylsalicylic acid and phenylacetic acid derivatives, including patients who experience asthma, bronchospasm, rhinitis, or urticaria following NSAID or aspirin. Formulation contains sodium sulfite, which may cause allergic-type reactions (including anaphylaxis and life-threatening or less severe asthmatic episodes) in certain susceptible individuals. May cause keratitis (risk of severe corneal adverse reactions). Diabetes mellitus or rheumatoid arthritis enhance risk of corneal adverse events. Use with caution in complicated ocular surgeries, corneal denervation, corneal epithelial defects, ocular surface disease, or repeat ocular surgeries within a short timeframe (risk of corneal adverse events). Use for more than 1 day prior to surgery or for 14 days beyond surgery may increase risk and severity of corneal adverse events. May slow or delay wound healing. May inhibit platelet aggregation and prolong bleeding time (caution in patients with underlying bleeding tendencies or in those receiving drugs known to prolong bleeding time). Patients using ophthalmic drops should not wear soft contact lenses.