Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Inhibits
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Belgium: Impromen; Germany: Impromen; Greece: Bromodol; Italy: Impromen.

Latin America

Argentina: Bromodol, Erodium.


Japan: Bromperidol, Impromen, Lunapron, Melkaick, Preperidol, Prindril.

Drug combinations


Bromperidol: C~21~H~23~NO~2~BrF. Mw: 420.32. (1) 1-Butanone,4-[4-(bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-; (2) 4-[4-(p-Bromophenyl)-4-hydroxypiperidinol]-4′-fluorobutyrophenone. CAS-10457-90-6 (1975).

Bromperidol Decanoate: C~31~H~41~BrFNO~3~. Mw: 574.56. Decanoic acid, 4-(4-bromophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl ester. CAS-75067-66-2 (1981).

Pharmacologic Category

Antipsychotics; Butyrophenone. (ATC-Code: N05AD06).

Mechanism of action

Potent dopaminergic D~2~ antagonist. Has weak α~1~-adrenolitic activity. It is a moderate serotonin 5-HT~2~ antagonist. Has no antihistaminic or anticholinergic effects. Its effect on delirium and hallucinations is due to its antidopaminergic action. This is probably due to its action on the mesocortex, limbic system, and basal ganglia (nigrostriate pathway). This last may justify its extrapyramidal effects. Its antidopaminergic action also explains its effects on nausea and vomiting, on gastrointestinal sphincters and the increase in prolactin liberation.

Therapeutic use

Schizophrenia. Other psychoses.

Pregnancy and lactiation implications

Teratogenic effects have not been shown in animals. Adequate studies have not been made in pregnant women. Use only when potential benefit to the woman outweighs possible risk to fetus. Excretion in breast milk unknown. Use with caution during lactation.

Unlabeled use


Hypersensitivity to bromperidol or any component of the formulation. CNS depression. Coma. Parkinson’s syndrome.

Warnings and precautions

Cases of sudden death have been described. May cause somnolence (concomitant consumption of alcohol may potentiate this effect). The elderly are more sensitive to extrapyramidal effects. Use not recommended in children under 12 years old. Risk of convulsions (caution in epileptic patients).



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