Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Drug Interactions
  • Dosage

Brand Names


Belgium: Miostat; Czech Republic: Miostat; France: Miostat; Germany: Carbamann, Isopto-Carbachol; Greece: Miostat; Hungary: Miostat; Luxembourg: Isopto Carbachol, Miostat; Netherlands: Miostat; Poland: Carbachol, Isopto Carbachol, Miostat; Romania: Miostat; Slovenia: Miostat; Sweden: Isopto Karbakolin, Miostat.

North America

Canada: Isopto Carbachol, Miostat; USA: Carbachol, Miostat.


Japan: Miostat.

Drug combinations


Carbachol: C~6~H~15~ClN~2~O~2~. Mw: 182.65. (1) Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride; (2) Choline chloride, carbamate. CAS-51-83-2.

Pharmacologic Category

Antiglaucoma Agents; Miotics. (ATC-Code: N07AB01; S01EB02).

Mechanism of action

Synthetic direct-acting cholinergic agent that causes miosis by stimulating muscarinic receptors in the eye.

Therapeutic use

To lower intraocular pressure in the treatment of glaucoma. To produce miosis during surgery.

Pregnancy and lactiation implications

No adequate studies conducted in pregnant women. Use with caution during pregnancy or lactation.

Unlabeled use


Hypersensitivity to carbachol or any component of the formulation. Acute iritis, acute inflammatory disease of the anterior chamber.

Warnings and precautions

It is suggested that intraocular carbachol does not produce the adverse effects of topically applied carbachol. Corneal clouding, persistent bullous keratopathy, retinal detachment and postoperative iritis following cataract extraction reported. Use with caution in asthma, in the presence of corneal abrasion, in peptic ulcer disease or gastrointestinal spasm, in acute heart failure, in hyperthyroidism, in Parkinson’s disease, in urinary tract obstruction, or in patients undergoing general anesthesia.



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