Carbinoxamine
- Atc Codes:R06AA08
- CAS Codes:3505-38-2#486-16-8
- PHARMGKB ID:3505-38-2#486-16-8
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Carbinoxamine.
Latin America
Argentina: Omega 100.
Drug combinations
Carbinoxamine and Pseudoephedrine
Carbinoxamine, Hydrocodone and Pseudoephedrine
Chemistry
Carbinoxamine Maleate: C~16~H~19~ClN~2~O C~4~H~4~O~4~. Mw: 406.86. (1) Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-, (Z)-2-butenedioate (1:1); (2) 2-[p-Chloro-α-[2-(dimethylamino)ethoxy]benzyl]pyridine maleate (1:1). CAS-3505-38-2; CAS-486-16-8 (carbinoxamine).
Pharmacologic Category
First Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AA08).
Mechanism of action
Ethanolamine antihistamine. Competes with histamine for H~1~-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. Blocks acetylcholine at muscarinic receptors. Has serotonin antagonist effects.
Therapeutic use
Seasonal and perennial allergic rhinitis. Vasomotor rhinitis. Urticaria. Decreases severity of other allergic reactions (conjunctivitis, angioedema, and dermatographism).
Pregnancy and lactiation implications
Animal reproduction studies have not been conducted. Contraindicated during lactation.
Unlabeled use
Contraindications
Hypersensitivity to carbinoxamine or any component of the formulation. Use with or within 14 days of MAO inhibitor therapy. Children <2 years of age. Breast-feeding.
Warnings and precautions
May cause CNS depression, which may impair physical or mental abilities. Concurrent use with psychotropics may produce additive sedation. Use with caution in history of asthma, cardiovascular disease (including hypertension and ischemic heart disease), increased intraocular pressure, prostatic hyperplasia and/or genitourinary obstruction, pyloroduodenal obstruction (including stenotic peptic ulcer) or thyroid dysfunction. Effects may be potentiated when used with other sedative drugs or ethanol. Use with caution in the elderly (may be more sensitive to adverse effects). Antihistamines may cause paradoxal excitation in young children.