Cefadroxil
- Atc Codes:J01DB05
- CAS Codes:66592-87-8#50370-12-2#119922-85-9
- PHARMGKB ID:66592-87-8#50370-12-2#119922-85-9
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Biodroxil, Duracef; Belgium: Cefadroxil, Duracef; Bulgaria: Biodroxil, Duracef; Cyprus: Amben, Cefadrox; Czech Republic: Biodroxil, Duracef; Estonia: Duracef; Finland: Cefadroxil, Duracef; France: Cefadroxil, Oracefal; Germany: Cefadroxil, Grüncef; Greece: Moxacef; Hungary: Duracef; Italy: Cefadril, Oradroxil; Latvia: Biodroxil, Duracef; Poland: Biodroxil, Droxef, Duracef, Tadroxil; Portugal: Cefacile, Cefadroxil, Ceforal; Romania: Cefadroxil, Cexil; Slovakia: Cedrox, Duracef; Spain: Cefadroxilo, Duracef; Sweden: Cefadroxil, Cefamox; UK: Baxan, Cefadroxil.
North America
Canada: Cefadroxil; USA: Cefadroxil, Duricef.
Latin America
Argentina: Cefacar, Cefacilina, Cefadrox, Cefamar, Cefatenk, Kandicín, Klondroxil, Versatic; Brazil: Cedroxil, Cefadroxil, Cefadroxila, Cefadroxón-Cefadroxil, Cefamox, Celocortín, Neo Cefadril; Mexico: Cefamox, Cepotec, Duracef, Inedif, Kefloxin, Teroxina.
Asia
Japan: Dolucefan, Salislon, Sumacef.
Drug combinations
Cefadroxil and Ambroxol
Chemistry
Cefadroxil: C~16~H~17~N~3~O~5~S H~2~O. Mw: 381.40. (1) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[amino(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-, monohydrate, [6R-[6α,7β(R*)]]-; (2)(6R,7R)-7-[(R)-2-Amino-2-(p-hydroxyphenyl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate. CAS-66592-87-8; CAS-50370-12-2 (anhydrous); CAS-119922-85-9 (hemihydrate)(1974).
Pharmacologic Category
Antibacterials; First Generation Cephalosporins. (ATC-Code: J01DB05).
Mechanism of action
Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins. Usually bactericidal. Inactive against anaerobic bacteria, fungi, and viruses. Active in vitro and in clinical infections against Gram-positive aerobic bacteria such as staphylococci (including penicillinase-producing strains), Streptococcus pyogenes (group A β-hemolytic streptococci), and S. pneumoniae. Oxacillin-resistant staphylococci (methicillin-resistant staphylococci) and most enterococci are resistant. Active in vitro and in clinical infections against Gram-negative aerobic bacteria such as Moraxella catarrhalis, Escherichia coli, Klebsiella, and Proteus mirabilis. Inactive against Acinetobacter, Enterobacter, Morganella morganii, P. vulgaris, and Pseudomonas.
Therapeutic use
Susceptible bacterial infections including group A β-hemolytic streptococcal pharyngitis or tonsillitis, skin and soft tissue infections caused by streptococci or staphylococci, and urinary tract infections caused by Klebsiella, E. coli, and Proteus mirabilis.
Pregnancy and lactiation implications
Adverse events were not observed in animal reproduction studies. Cefadroxil crosses the placenta. Adequate studies have not been completed in pregnant women. Use with caution.
Unlabeled use
Contraindications
Hypersensitivity to cefadroxil, any component of the formulation, or other cephalosporins.
Warnings and precautions
Use with caution in history of penicillin allergy, especially IgE-mediated reactions (e.g. anaphylaxis, angioedema, urticaria). Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Use with caution in renal impairment. May cause positive direct Coombs’, false-positive urinary glucose test using cupric sulfate, false-positive serum or urine creatinine with Jaffé reaction. Prolonged use may result in superinfection. In neonates, risk of «gasping syndrome» (potentially fatal) due to consumption of benzoic acid (present in oral suspension).