May be associated with increased INR, especially in nutritionally-deficient patients, prolonged treatment, hepatic or renal disease. Partial cross-sensitivity among cephalosporins and other β-lactam antibiotics, including penicillins and cephamycins (caution in patients with history of penicillin allergy; avoid use in those who have had an immediate-type (anaphylactic) hypersensitivity reaction and administer with caution in those who have had a delayed-type). Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea, and pseudomembranous colitis. Use with caution in renal impairment. Possible increased risk of renal toxicity in patients >50 years of age. Use with caution in history of seizure disorder (high levels, particularly in the presence of renal impairment, may increase risk of seizures). May cause positive direct Coombs’, false-positive urinary glucose test using cupric sulfate, false-positive serum or urine creatinine with Jaffé reaction. Some penicillin derivatives may accelerate the degradation of aminoglycosides in vitro, leading to a potential underestimation of aminoglycoside serum concentration. May cause possible emergence and overgrowth of nonsusceptible organisms, especially Enterobacter, Pseudomonas, Enterococci, or Candida. Use with caution in history of GI disease, particularly colitis. Prolonged PT reported with some cephalosporins. Use only for treatment or prevention of infections proven or strongly suspected to be caused by susceptible bacteria. Caution in overt or known subclinical diabetes mellitus or in carbohydrate intolerance (may contain dextrose). Commercial form contains sodium.