Cephradine
- Atc Codes:J01DB09
- CAS Codes:38821-53-3#58456-86-3#31828-50-9
- PHARMGKB ID:38821-53-3#58456-86-3#31828-50-9
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
France: Cefadrine, Dexet; Ireland: Velosef; Poland: Tafril; Portugal: Biocefra, Cefalmin, Cefadrina, Cefradur; UK: Velosef.
North America
USA: Velosef.
Drug combinations
Chemistry
Cephradine: C~16~H~19~N~3~O~4~S. Mw: 349.40. (1) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(amino-1,4-cyclohexadien-1-ylacetyl)amino]-3-methyl-8-oxo-, [6R-[6α,7β(R*)]]-; (2) (6R,7R)-7-[(R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. CAS-38821-53-3 (anhydrous); CAS-58456-86-3 (dihydrate); CAS-31828-50-9 (non-stoichiometric hydrate)(1971).
Pharmacologic Category
Antibacterials; First Generation Cephalosporins. (ATC-Code: J01DB09).
Mechanism of action
Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins. Usually bactericidal. Active in vitro and in clinical infections against Gram-positive aerobic bacteria, such as Staphylococcus aureus and S. epidermidis (including penicillinase-producing strains), Streptococcus pyogenes (group A β-hemolytic streptococci), and S. pneumoniae. Oxacillin-resistant (methicillin-resistant) staphylococci and most enterococci are resistant. Active in vitro and in clinical infections against Gram-negative aerobic bacteria such as Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Inactive against anaerobic bacteria, fungi, and viruses.
Therapeutic use
Infections caused by susceptible strains in respiratory, genitourinary, gastrointestinal, skin and soft tissue, bone and joint infections. Susceptible Gram-positive bacilli and cocci (never enterococcus).
Pregnancy and lactiation implications
Crosses placenta. Enters breast milk. Use caution.
Unlabeled use
Contraindications
Hypersensitivity to cephradine, any component, or cephalosporins.
Warnings and precautions
Prolonged use may result in superinfection. Do not use in immediate-type hypersensitivity reaction to penicillin. Use with caution in renal impairment. May cause positive direct Coombs’ test, false-positive urinary glucose test using cupric sulfate, and false-positive serum or urine creatinine with Jaffé reaction.