Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: CetirHexal, Cetiristad, Cetirizin, Tirizin, Zyrtec; Belgium: Cetirizine, Cetisandoz, Histimed, Hyperpoll, Reactine, Zyrtec; Bulgaria: Allersan, Cetirinax, Cetiristad, Cetirizin, Cetlectec, Egirizin, Letizen, Talert, Zodac, Zyrtec; Cyprus: Agelmin, Cetirizin, Cetirizine, Cirizine, Temelin, Zirex, Zyrtec; Czech Republic: Alerid, Analergin, Cerex, Cetirizin, Cetirizine, Letizen, Parlazin, Reactine, Zodac, Zyrtec; Denmark: Alnok, Benaday, Cetirizin, Vialerg, Zyrtec; Estonia: Aceterin, Cetirizin, Zyrtec; Finland: Alzyr, Cetirizin, Heinix, Histanova, Histec, Lomfast, Senirex, Zyrtec; France: Actifed Allergie Cetirizine, Alairgix, Cetirizine, Humex Allergie Cetirizine, Virlix, Zyrtec; Germany: Cetalerg, Ceterifug, Ceti TAD, Cetiderm, Cetidura, CetiLich, Cetir Akut, Cetirigamma, Cetirizin, Reactine, Zetir Saft, Zyrtec; Greece: Agelmin, Alenstran, Alergoxal, Arzedyn, Blezamont, Cetiram, Cetirgen, Cetril, Cirizine, Dermizin, Gentiran, Habitek, Hamiltosin, Histafren, Ralizon, Remezine, Rezerc, Tasker, Telarix, Vitinelin, Zeda, Zepholin, Ziptek, Znupril; Hungary: Alerid, Cetigen, Cetino, Cetirizin, Cetrin Akuv, Parlazin, Zyrtec; Ireland: Cetirelief Allergy, Cetirizine, Cetricure, Cetrine, Cetriz, Histek, Reactine, Tiritek Allergy, Zirpine, Zirtek, Zirtene; Italy: Cerchio, Ceteris, Cetirizina, Formistin, Kruzin, Reactidiem, Rinalgit, Sotrizol, Stamidix, Suspiria, Tezastin, Zyrtec; Latvia: Aceterin, Cetirizin, Parlazin, Zyrtec; Lithuania: Aceterin, Cetirizin, Letizen, Parlazin, Zyrtec; Luxembourg: Zyrtec; Malta: Cetiram, Cetirizine, Zirex, Zyrtec; Netherlands: Cetirizine, Prevalin Allerstop, Reactine, Zyrtec; Poland: Alermed, Alero, Alerzina, Allertec, Amefar, Amertil, CetAlergin, Cetelerik, Cetiozone, Cetirizine, Cetrid, Cetrivax, Cetrizen, Cetyryzyna, Letizen, Reactine, Ubercet, Virlix, Zodac, Zyrtec; Portugal: Cetirizina, Cetix, Cinaz, Rinoliber, Virlix, Zyrtec; Romania: Alerid, Analergin, Celerg, Cetirizin, Cetirizine, Letizen, Zyrtec; Slovakia: Alerid, Cetigen, Cetirizin, Cetirizine, Letizen, Reactine, Zodac, Zyrtec; Slovenia: Cetirizin, Letizen, Zyrtec; Spain: Alercina, Alerlisin, Cetirizina, Coulergin, Reactine, Virlix, Zyrtec; Sweden: Acura, Alnok, Cetidura, Cetiristad, Cetirizin, Cidron, Reactine, Zyrlex, Zyrtec; UK: Benadryl Allergy Oral Syrup, Benadryl for Children Allergy Solution, Benadryl One A Day, Cetirizine, Piriteze Allergy Syrup, Pollenshield Hayfever, Zirtek Allergy.

North America

Canada: Aller-Relief, Allergy-Relief, Cetirizine, Reactine; USA: Cetirizine, Zyrtec.

Latin America

Argentina: Alernix 24, Atopix, Cabal, Cetidac, Cetirizina, Cetizine, Cetriler, Stopaler; Brazil: Aletir, Cetirizina, Cetrizin, Zetir, Zinetrín, Zyrtec; Mexico: Apoliz, Cetitev, Dercetina, Kenicet, Namitace, Reactine, Virlix, Visertral, Zyrtec.


Japan: Cetirizine, Zyrtec.

Drug combinations

Cetirizine and Pseudoephedrine


Cetirizine Hydrochloride: C~21~H~25~ClN~2~O~3~ 2HCl. Mw: 461.81. (1) Acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride, (±)-; (2)(±)-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]acetic acid, dihydrochloride. CAS-83881-52-1; CAS-83881-51-0 (cetirizine)(1985).

Pharmacologic Category

Second Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AE07).

Mechanism of action

A metabolite of hydroxyzine, it is a selective antagonist of peripheral histamine H~1~-receptors on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. Tolerance to antihistaminic effect does not usually occur. Does not show appreciable anticholinergic or antiserotonergic effects in animal models.

Therapeutic use

Perennial and seasonal allergic rhinitis and other allergic symptoms including urticaria. Chronic idiopathic urticaria.

Pregnancy and lactiation implications

Not teratogenic in animal studies. Adequate studies not conducted in pregnant women. Use during pregnancy only if clearly needed. Enters breast milk.

Unlabeled use


Hypersensitivity to cetirizine, hydroxyzine, or any component of the formulation.

Warnings and precautions

May cause CNS depression. Use with caution in hepatic or renal impairment. Use with caution in the elderly (more sensitive to adverse effects).



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