Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Inhibits
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


France: Broncalene Nourrissons; Germany: Balkis Dr. Henk Schnupfenkapseln Neu, Chlorphen, Polaronil, Snup; Greece: Istamex; Ireland: Chlorphenamine, Piriton; Italy: Trimeton; Romania: Clorfeniramin; Spain: Antihistamínico Llorens; UK: Chlorphenamine.

North America

Canada: Chlor-Tripolon, Chlorpheniramine, Novo-Pheniram; USA: Chlor-Trimeton, Chlorpheniramine.

Latin America

Argentina: Alergidryl, Alergitrat, Clorfeniramina; Mexico: Alerdil, Antadex-H, Bioflusin, Clorfenamina, Cronal, Docsi, Histadryl Tab., Pirafrin.


Japan: Allergin, Animing, Bismilla, Chlodamin, Chlorpheniramine, Chlor-trimeton, Histal, Magotimin, Maleramine, Neomallermin, Neorestamin, Neorestar, Neovenacon, Pheniramin, Polazit.

Drug combinations

Chlorpheniramine and Acetaminophen

Chlorpheniramine and Dexamethasone

Chlorpheniramine and Dextromethorphan

Chlorpheniramine and Ephedrine

Chlorpheniramine and Epinephrine

Chlorpheniramine and Hydrocodone

Chlorpheniramine and Phenylephrine

Chlorpheniramine and Pseudoephedrine

Chlorpheniramine and Tetrahydrozoline

Chlorpheniramine and Triamcinolone

Chlorpheniramine, Acetaminophen, and Ascorbic Acid (Vitamin C)

Chlorpheniramine, Acetaminophen, and Phenylephrine

Chlorpheniramine, Acetaminophen, and Pseudoephedrine

Chlorpheniramine, Amantadine, and Acetaminophen

Chlorpheniramine, Ammonium Chloride, and Dextromethorphan

Chlorpheniramine, Aspirin, and Caffeine

Chlorpheniramine, Aspirin, and Phenylephrine

Chlorpheniramine, Codeine, and Pseudoephedrine

Chlorpheniramine, Dexamethasone, and Ephedrine

Chlorpheniramine, Dextromethorphan, and Ephedrine

Chlorpheniramine, Dextromethorphan, and Phenylephrine

Chlorpheniramine, Dextromethorphan, and Pseudoephedrine

Chlorpheniramine, Dihydrocodeine, and Pseudoephedrine

Chlorpheniramine, Hydrocodone, and Pseudoephedrine

Chlorpheniramine, Ibuprofen, and Pseudoephedrine

Chlorpheniramine, Methscopolamine, and Pseudoephedrine

Chlorpheniramine, Acetaminophen, Ascorbic Acid (Vitamin C), and Caffeine

Chlorpheniramine, Acetaminophen, Bromhexine, and Pseudoephedrine

Chlorpheniramine, Acetaminophen, Butetamate, and Pseudoephedrine

Chlorpheniramine, Acetaminophen, Caffeine, and Ergotamine

Chlorpheniramine, Acetaminophen, Dextromethorphan, and Pseudoephedrine

Chlorpheniramine, Acetaminophen, Guaifenesin, and Phenylephrine

Chlorpheniramine, Codeine, Phenylephrine and Potassium Iodide

Chlorpheniramine, Dexamethasone, Naphazoline, and Neomycin

Chlorpheniramine, Dextromethorphan, Ephedrine, and Guaifenesin

Chlorpheniramine, Dextromethorphan, Guaifenesin, and Phenylephrine

Chlorpheniramine, Carbetapentane, Ephedrine, and Phenylephrine

Chlorpheniramine, Gramicidin, Neomycin, and Phenylephrine

Chlorpheniramine, Acetaminophen, Bromhexine, Dextromethorphan, and Phenylephrine

Chlorpheniramine, Caffeine, Dipyrone, Ergotamine, and Metoclopramide

Chlorpheniramine, Aluminum Hydroxide, Ascorbic Acid (Vitamin C), Aspirin, Caffeine, and Magnesium Carbonate


Chlorpheniramine Maleate: C~16~H~19~ClN~2~ C~4~H~4~O~4~. Mw: 390.86. (1) 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1); (2) 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine maleate (1:1). CAS-113-92-8; CAS-132-22-9 (chlorpheniramine).

Pharmacologic Category

First Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AB04).

Mechanism of action

Blocks H~1~-receptor sites and prevents the action of histamine on the cell. Suppresses flare and pruritus that accompany the endogenous release of histamine. Antihistamines do not block the stimulant effect of histamine on gastric acid secretion, which is mediated by H~2~-receptors of parietal cells.

Therapeutic use

Perennial and seasonal allergic rhinitis. Other allergic symptoms such as urticaria.

Pregnancy and lactiation implications

Reproduction studies not conducted. Excretion in breast milk unknown.

Unlabeled use


Hypersensitivity to chlorpheniramine maleate or any component of the formulation. Narrow-angle glaucoma. Bladder neck obstruction. Symptomatic prostate hypertrophy. Acute asthmatic attacks. Stenosing peptic ulcer. Pyloroduodenal obstruction. Avoid use in premature and term newborns.

Warnings and precautions

May cause CNS depression. Use with caution in cardiovascular disease (including hypertension and ischemic heart disease). Use with caution in increased intraocular pressure. Use with caution in prostatic hyperplasia and/or genitourinary obstruction. Use with caution in asthma or other chronic breathing disorders. Use with caution in thyroid dysfunction. Effects may be potentiated when used with other sedative drugs or ethanol. Use with caution in the elderly (higher risk of adverse effects). Antihistamines may cause excitation in young children (do not use in children <2 years of age).



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