Chlorpheniramine
- Atc Codes:R06AB04
- CAS Codes:113-92-8#132-22-9
- PHARMGKB ID:113-92-8#132-22-9
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
France: Broncalene Nourrissons; Germany: Balkis Dr. Henk Schnupfenkapseln Neu, Chlorphen, Polaronil, Snup; Greece: Istamex; Ireland: Chlorphenamine, Piriton; Italy: Trimeton; Romania: Clorfeniramin; Spain: Antihistamínico Llorens; UK: Chlorphenamine.
North America
Canada: Chlor-Tripolon, Chlorpheniramine, Novo-Pheniram; USA: Chlor-Trimeton, Chlorpheniramine.
Latin America
Argentina: Alergidryl, Alergitrat, Clorfeniramina; Mexico: Alerdil, Antadex-H, Bioflusin, Clorfenamina, Cronal, Docsi, Histadryl Tab., Pirafrin.
Asia
Japan: Allergin, Animing, Bismilla, Chlodamin, Chlorpheniramine, Chlor-trimeton, Histal, Magotimin, Maleramine, Neomallermin, Neorestamin, Neorestar, Neovenacon, Pheniramin, Polazit.
Drug combinations
Chlorpheniramine and Acetaminophen
Chlorpheniramine and Dexamethasone
Chlorpheniramine and Dextromethorphan
Chlorpheniramine and Ephedrine
Chlorpheniramine and Epinephrine
Chlorpheniramine and Hydrocodone
Chlorpheniramine and Phenylephrine
Chlorpheniramine and Pseudoephedrine
Chlorpheniramine and Tetrahydrozoline
Chlorpheniramine and Triamcinolone
Chlorpheniramine, Acetaminophen, and Ascorbic Acid (Vitamin C)
Chlorpheniramine, Acetaminophen, and Phenylephrine
Chlorpheniramine, Acetaminophen, and Pseudoephedrine
Chlorpheniramine, Amantadine, and Acetaminophen
Chlorpheniramine, Ammonium Chloride, and Dextromethorphan
Chlorpheniramine, Aspirin, and Caffeine
Chlorpheniramine, Aspirin, and Phenylephrine
Chlorpheniramine, Codeine, and Pseudoephedrine
Chlorpheniramine, Dexamethasone, and Ephedrine
Chlorpheniramine, Dextromethorphan, and Ephedrine
Chlorpheniramine, Dextromethorphan, and Phenylephrine
Chlorpheniramine, Dextromethorphan, and Pseudoephedrine
Chlorpheniramine, Dihydrocodeine, and Pseudoephedrine
Chlorpheniramine, Hydrocodone, and Pseudoephedrine
Chlorpheniramine, Ibuprofen, and Pseudoephedrine
Chlorpheniramine, Methscopolamine, and Pseudoephedrine
Chlorpheniramine, Acetaminophen, Ascorbic Acid (Vitamin C), and Caffeine
Chlorpheniramine, Acetaminophen, Bromhexine, and Pseudoephedrine
Chlorpheniramine, Acetaminophen, Butetamate, and Pseudoephedrine
Chlorpheniramine, Acetaminophen, Caffeine, and Ergotamine
Chlorpheniramine, Acetaminophen, Dextromethorphan, and Pseudoephedrine
Chlorpheniramine, Acetaminophen, Guaifenesin, and Phenylephrine
Chlorpheniramine, Codeine, Phenylephrine and Potassium Iodide
Chlorpheniramine, Dexamethasone, Naphazoline, and Neomycin
Chlorpheniramine, Dextromethorphan, Ephedrine, and Guaifenesin
Chlorpheniramine, Dextromethorphan, Guaifenesin, and Phenylephrine
Chlorpheniramine, Carbetapentane, Ephedrine, and Phenylephrine
Chlorpheniramine, Gramicidin, Neomycin, and Phenylephrine
Chlorpheniramine, Acetaminophen, Bromhexine, Dextromethorphan, and Phenylephrine
Chlorpheniramine, Caffeine, Dipyrone, Ergotamine, and Metoclopramide
Chlorpheniramine, Aluminum Hydroxide, Ascorbic Acid (Vitamin C), Aspirin, Caffeine, and Magnesium Carbonate
Chemistry
Chlorpheniramine Maleate: C~16~H~19~ClN~2~ C~4~H~4~O~4~. Mw: 390.86. (1) 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1); (2) 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine maleate (1:1). CAS-113-92-8; CAS-132-22-9 (chlorpheniramine).
Pharmacologic Category
First Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AB04).
Mechanism of action
Blocks H~1~-receptor sites and prevents the action of histamine on the cell. Suppresses flare and pruritus that accompany the endogenous release of histamine. Antihistamines do not block the stimulant effect of histamine on gastric acid secretion, which is mediated by H~2~-receptors of parietal cells.
Therapeutic use
Perennial and seasonal allergic rhinitis. Other allergic symptoms such as urticaria.
Pregnancy and lactiation implications
Reproduction studies not conducted. Excretion in breast milk unknown.
Unlabeled use
Contraindications
Hypersensitivity to chlorpheniramine maleate or any component of the formulation. Narrow-angle glaucoma. Bladder neck obstruction. Symptomatic prostate hypertrophy. Acute asthmatic attacks. Stenosing peptic ulcer. Pyloroduodenal obstruction. Avoid use in premature and term newborns.
Warnings and precautions
May cause CNS depression. Use with caution in cardiovascular disease (including hypertension and ischemic heart disease). Use with caution in increased intraocular pressure. Use with caution in prostatic hyperplasia and/or genitourinary obstruction. Use with caution in asthma or other chronic breathing disorders. Use with caution in thyroid dysfunction. Effects may be potentiated when used with other sedative drugs or ethanol. Use with caution in the elderly (higher risk of adverse effects). Antihistamines may cause excitation in young children (do not use in children <2 years of age).