May alter cardiac conduction (risk of life-threatening arrhythmias). Use with caution in severe cardiovascular disease. May cause orthostatic hypotension (caution if cerebrovascular disease, cardiovascular disease, hypovolemia, or concurrent medication use which may predispose to hypotension/bradycardia). May cause anticholinergic effects (constipation, xerostomia, blurred vision, urinary retention; caution in decreased gastrointestinal motility, paralytic ileus, urinary retention, BPH, xerostomia, or visual problems). Antipsychotic use has been associated with esophageal dysmotility and aspiration (caution if risk of pneumonia). May cause extrapyramidal symptoms, including pseudoparkinsonism, acute dystonic reactions, akathisia, and tardive dyskinesia (caution in the elderly). May be associated with neuroleptic malignant syndrome (higher risk if Parkinson’s disease or Lewy body dementia). Highly sedating. Use with caution in patients at risk of seizures (history of seizures, head trauma, brain damage, alcoholism, or concurrent therapy which may lower seizure threshold). Use with caution in myasthenia gravis (may be exacerbated by cholinergic blockade). Elderly patients with dementia-related psychosis treated with antipsychotics are at increased risk of death compared to placebo (risk of cerebrovascular events). Effects may be potentiated when used with other sedative drugs or ethanol. May be associated with pigmentary retinopathy. Use with caution in narrow-angle glaucoma (may be exacerbated by cholinergic blockade). Impaired core body temperature regulation may occur. Use with caution in bone marrow suppression (risk of blood dyscrasias). Use with caution in hepatic/renal/respiratory impairment. Use with caution in breast cancer or other prolactin-dependent tumors (elevates prolactin levels). May mask toxicity of other drugs or conditions (e.g. intestinal obstruction, Reye’s syndrome, brain tumor) due to antiemetic effects. Injection contains sulfites. May cause false-positives for phenylketonuria, amylase, uroporphyrins, urobilinogen. May cause false-positive pregnancy test.