Clotrimazole
- Atc Codes:A01AB18#D01AC01#G01AF02
- CAS Codes:23593-75-1
- PHARMGKB ID:23593-75-1
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Inhibits
- Induces
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Candibene, Canesten Clotrimazol, Clotrimazol, Imazol Paste, Pedikurol; Belgium: Canestene Derm Clotrimazole; Bulgaria: Canesten, Clotrimazole, Imazol Paste; Cyprus: Antifungol, Canesten, Mycoril, Warimazol; Czech Republic: Aknecolor Krémpasta, Candibene, Canesten, Canifug, Clotricyd, Clotrimazol, Imazol Krémpasta, Jenamazol; Denmark: Canesten; Estonia: Canifug, Imazol, Klotrimasool; Finland: Canesten; Germany: Antifungol, Apocanda, Benzoderm Myco, Canesten, Canifug, Clotri OPT, Clotrigalen, Clotrikad-Crème, Clotrimazol, Cutistad, Fungiderm, Fungikad, Fungizid, Gilt, Imazol Paste, Jenamazol, KadeFungin, Mycofug, Myko Cordes, Mykofungin, Mykohaug, Onymyken, SD-Hermal Minuten-Crème, Suprazol, Uromykol, Warimazol; Greece: Canesten, Factodin; Hungary: Candibene, Canesten, Canifug, Clotrimazole, Imamono; Ireland: Canazole Clotrimazole, Canesten; Italy: Antimicotico Same, Canesten, Cangil, Clotrimazolo; Latvia: Aknecolor, Canifug, Clotrimazolum, Klotrimazol, Lithuania: Aknecolor, Canifug, Clotrimazolum, Klotrimazolis; Luxembourg: Antifungol, Canestene, Fungizid; Malta: Canesten, Clotrimazole, Mycoril; Netherlands: Canesten, Clotrimazol, Imazol Paste; Poland: Canesten, Clotrimazol, Clotrimazolum, Fungizid, Imazol; Portugal: Canesten, Clotrimazol, Diomicete, Lotremine, Micolysin, Nalbix, Pan-Fungex; Romania: Canesten, Clotrimazol, Dermatin, Imazol Pasta; Slovakia: Aknecolor Krémpasta, Candibene, Canesten, Canifug, Clotrimazol, Clotrimazolum, Imazol Krémpasta, Jenamazol; Slovenia: Canesten, Canifug; Spain: Canespie, Canesten, Clotrimazol; Sweden: Canesten, Klotrimazol; UK: Canesten, Clotrimazole.
North America
Canada: Canesten, Clotrimaderm, Clotrimazole; USA: Clotrimazole, Mycelex.
Latin America
Argentina: Aflorix, Clotrimazol, Clotrix, Dr. Scholl’s, Empecid, Eximius, Fiasole, Fungocop Premium, Ikolan, Klomazole, Medifungol, Micoclin, Micomazol, Micosep, Mycaden, Panmicol, Permykot, Sinfung, Trimazol; Brazil: Antimicótico Martel, Canesten, Clomazen, Clomazol, Clotren, Clotriderm, Clotrimazol, Clotrizan, Dermobene, Gino-Clotrimix, Kinasten, Micotrat, Neo Clotrimazyl; Mexico: Altenal, Candimon, Candiphen, Canesten, Clocan, Clomacin, Dermasten, Euroderm, Liferzol, Lomecan V, Rangyn, Tenescan, Toczol.
Asia
Japan: Clostrin, Clotrimazole, Elcid, Empecid, Enschent, Hakuserin, Kotozole, Taon.
Drug combinations
Clotrimazole and Betamethasone
Clotrimazole and Fluconazole
Clotrimazole and Hexamidine
Clotrimazole and Hydrocortisone
Clotrimazole and Metronidazole
Clotrimazole and Urea
Clotrimazole and Zinc Oxide
Clotrimazole, Betamethasone, and Gentamicin
Clotrimazole, Dexamethasone, and Marbofloxacin
Clotrimazole, Hexamidine and Prednisolone
Clotrimazole, Nitrofurazone, Streptomycin, and Tyrothricin
Chemistry
Clotrimazole: C~22~H~17~ClN~2~. Mw: 344.84. (1) 1H-Imidazole, 1-[(2-chlorophenyl)diphenylmethyl]-; (2) 1-(o-Chloro-α,α-diphenylbenzyl)imidazole. CAS-23593-75-1 (1970).
Pharmacologic Category
Skin and Mucous Membrane Agents; Antifungals; Azoles. Topical. (ATC-Code: A01AB18; D01AC01; G01AF02).
Mechanism of action
Imidazole-derivative azole antifungal. Fungistatic or fungicidal against many fungi, including yeasts and dermatophytes. Active against some Gram-positive bacteria. Binds phospholipids in fungal cell membrane and alters cell membrane permeability, leading to loss of cellular constituents. Active in vitro and in clinical infections caused by most strains of T. rubrum, T. mentagrophytes, E. floccosum, and M. canis. Less active against M. furfur (P. orbiculare), Aspergillus fumigatus, C. albicans. Also active in vitro against Sporothrix, Cryptococcus, Cephalosporium, and Fusarium.
Therapeutic use
Susceptible fungal infections (oropharyngeal candidiasis, dermatophytoses, superficial mycoses, cutaneous candidiasis, vulvovaginal candidiasis).
Pregnancy and lactiation implications
There are no adequate studies in pregnant women. Clotrimazole lozenges should be used during pregnancy only when the potential benefits justify the possible risks to the fetus. Clotrimazole topical cream, lotion, and solution should be used during the first trimester of pregnancy only if clearly indicated. Use with caution in lactation.
Unlabeled use
Contraindications
Hypersensitivity to clotrimazole or any component of the formulation.
Warnings and precautions
Clotrimazole should not be used for treatment of systemic fungal infection.