Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Inhibits
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Echnatol; Denmark: Marzine; Finland: Marzine; Ireland: Valoid; Malta: Valoid; Netherlands: Cyclizine; UK: Valoid.

Drug combinations

Cyclizine and Morphine


Cyclizine Hydrochloride: C~18~H~22~N~2~ HCl. Mw: 302.84. (1) Piperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride; (2) 1-(Diphenylmethyl)-4-methylpiperazine monohydrochloride. CAS-303-25-3; CAS-82-92-8 (cyclizine).

Cyclizine Lactate: C~18~H~22~N~2~ C~3~H~6~O~3~. Mw: 356.46. 1-(Diphenylmethyl)-4-methylpiperazine monolactate. CAS-5897-19-8.

Pharmacologic Category

First Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AE03).

Mechanism of action

Cyclizine is a piperazine derivative with properties of histamines. Inhibits the symptoms of motion sickness by an unknown mechanism. Has a central anticholinergic action.

Therapeutic use

Prevention and treatment of nausea, vomiting, and vertigo associated with motion sickness. Postoperative nausea and vomiting.

Pregnancy and lactiation implications

Unlabeled use


Hypersensitivity to cyclizine or any component of the formulation.

Warnings and precautions

Due to its anticholinergic action, use with caution in angle-closure glaucoma, prostate hyperplasia, constipation, or GI obstructive disease (higher risk in elder patients).



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