Cyclizine

Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Inhibits
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names

Europe

Austria: Echnatol; Denmark: Marzine; Finland: Marzine; Ireland: Valoid; Malta: Valoid; Netherlands: Cyclizine; UK: Valoid.

Drug combinations

Cyclizine and Morphine

Chemistry

Cyclizine Hydrochloride: C~18~H~22~N~2~ HCl. Mw: 302.84. (1) Piperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride; (2) 1-(Diphenylmethyl)-4-methylpiperazine monohydrochloride. CAS-303-25-3; CAS-82-92-8 (cyclizine).

Cyclizine Lactate: C~18~H~22~N~2~ C~3~H~6~O~3~. Mw: 356.46. 1-(Diphenylmethyl)-4-methylpiperazine monolactate. CAS-5897-19-8.

Pharmacologic Category

First Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AE03).

Mechanism of action

Cyclizine is a piperazine derivative with properties of histamines. Inhibits the symptoms of motion sickness by an unknown mechanism. Has a central anticholinergic action.

Therapeutic use

Prevention and treatment of nausea, vomiting, and vertigo associated with motion sickness. Postoperative nausea and vomiting.

Pregnancy and lactiation implications

Unlabeled use

Contraindications

Hypersensitivity to cyclizine or any component of the formulation.

Warnings and precautions

Due to its anticholinergic action, use with caution in angle-closure glaucoma, prostate hyperplasia, constipation, or GI obstructive disease (higher risk in elder patients).

Information

Legal

Legal Notice
Privacy Policy
Cookie Policy

Contact

Phone: +34-981-780505
Email: genomicmedicine@wagem.org
Location: Sta Marta de, C. P. Babío, S/N, 15165 Bergondo, A Coruña

Copyright © 2023 WAGEM

Add to cart