Cyclizine
- Atc Codes:R06AE03
- CAS Codes:303-25-3#82-92-8#5897-19-8
- PHARMGKB ID:303-25-3#82-92-8#5897-19-8
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Echnatol; Denmark: Marzine; Finland: Marzine; Ireland: Valoid; Malta: Valoid; Netherlands: Cyclizine; UK: Valoid.
Drug combinations
Cyclizine and Morphine
Chemistry
Cyclizine Hydrochloride: C~18~H~22~N~2~ HCl. Mw: 302.84. (1) Piperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride; (2) 1-(Diphenylmethyl)-4-methylpiperazine monohydrochloride. CAS-303-25-3; CAS-82-92-8 (cyclizine).
Cyclizine Lactate: C~18~H~22~N~2~ C~3~H~6~O~3~. Mw: 356.46. 1-(Diphenylmethyl)-4-methylpiperazine monolactate. CAS-5897-19-8.
Pharmacologic Category
First Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AE03).
Mechanism of action
Cyclizine is a piperazine derivative with properties of histamines. Inhibits the symptoms of motion sickness by an unknown mechanism. Has a central anticholinergic action.
Therapeutic use
Prevention and treatment of nausea, vomiting, and vertigo associated with motion sickness. Postoperative nausea and vomiting.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Hypersensitivity to cyclizine or any component of the formulation.
Warnings and precautions
Due to its anticholinergic action, use with caution in angle-closure glaucoma, prostate hyperplasia, constipation, or GI obstructive disease (higher risk in elder patients).