Dicloxacillin
- Atc Codes:J01CF01
- CAS Codes:13412-64-1#343-55-5#3116-76-5
- PHARMGKB ID:13412-64-1#343-55-5#3116-76-5
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Induces
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Denmark: Dicillin, Diclocil; Finland: Diclocil; Germany: Infectostaph; Greece: Diclocil; Portugal: Diclocil; Sweden: Diclocil.
North America
USA: Dicloxacillin.
Latin America
Mexico: Antiben, Brispen, Butimaxil, Clobioxal, Dic-Fhi, Dicleophen, Diclotecno, Dicloxacilina, Dicloxaquim, Diluxina, Dimicin, Ditterolina, Dixen, Pardix, Penclox, Posipen.
Drug combinations
Chemistry
Dicloxacillin Sodium: C~19~H~16~Cl~2~N~3~NaO~5~S.H~2~O. Mw: 510.32. (1) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6β)]-; (2) Monosodium (2S,5R,6R)-6-[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrate. CAS-13412-64-1; CAS-343-55-5 (anhydrous); CAS-3116-76-5 (dicloxacillin)(1968).
Pharmacologic Category
Antibacterials; Penicillinase-resistant Penicillins. (ATC-Code: J01CF01).
Mechanism of action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
Therapeutic use
Treatment of systemic infections such as pneumonia, skin and soft tissue infections, and osteomyelitis caused by penicillinase-producing staphylococci. Treatment of orofacial infections.
Pregnancy and lactiation implications
Crosses the placenta. Teratogenic effects not reported with dicloxacillin, but there are no adequate, well-controlled studies in pregnant women. Other penicillins are considered safe for use in pregnancy or during breast-feeding. Caution when administering dicloxacillin to nursing women.
Unlabeled use
Contraindications
Hypersensitivity to dicloxacillin, penicillin, or any component of the formulation.
Warnings and precautions
Hypersensitivity (anaphylactoid) reactions reported. Use with caution in asthmatic patients. Prolonged use may result in fungal or bacterial superinfection (including C. difficile-associated diarrhea and pseudomembranous colitis). Caution in neonates (slow elimination of drug).