Econazole
- Atc Codes:D01AC03#G01AF05
- CAS Codes:68797-31-9#27220-47-9
- PHARMGKB ID:68797-31-9#27220-47-9
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Inhibits
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Pevaryl; Belgium: Pevaryl; Bulgaria: Econazole, Pevaryl; Cyprus: Pevaryl P V; Czech Republic: Pevaryl; Denmark: Pevaryl; Estonia: Gyno-Pevaryl; Finland: Pevaryl; France: Dermazol, Econazole, Fongeryl, Fongileine, Myco Apaisyl, Myleugyn LP, Pevaryl; Germany: Epi-Pevaryl, Gyno-Pevaryl; Greece: Fungistat, Mycobacter, Pevaryl; Hungary: Pevaryl; Ireland: Gyno-Pevaryl; Italy: Ecodergin, Ecomesol CR, Ecomi’, Econazolo, Ecorex, Ecosteril, Ganazolo, Ifenec, Micos, Pevaryl, Polinazolo; Latvia: Gyno-Pevaryl; Lithuania: Gyno-Pevaryl; Luxembourg: Gyno-Pevaryl; Netherlands: Pevaryl; Poland: Mitekol, Pevaryl, Pevazol; Portugal: Pevaryl; Romania: Econazol; Slovakia: Gyno-Pevaryl; Spain: Micoespec; Sweden: Pevaryl; UK: Pevaryl.
North America
USA: Econazole, Spectazole.
Latin America
Argentina: Dermocitrán, Excelentia Antimicótico, Micocide, Micolis, Micotes, Nomicon, Novo-Paramicón, Sinamida Econazol Fungicida; Brazil: Micostyl; Mexico: Arecolex, Micostyl, Pevaryl Lipogel.
Asia
Japan: Palavale.
Drug combinations
Econazole and Triamcinolone
Econazole, Diflorasone, and Gentamicin
Econazole, Boric Acid, Griseofulvin Hydrocortisone, Neomycin and Salicylic Acid
Econazole, Diflorasone, Gentamicin, Griseofulvin, Hydrocortisone, Neomycin, and Salicylic Acid
Chemistry
Econazole Nitrate: C~18~H~15~Cl~3~N~2~O HNO~3~. Mw: 444.70. (1) 1H-Imidazole, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-, mononitrate, (±)-; (2)(±)-1-[2,4-Dichloro-β-[(p-chlorobenzyl)oxy]phenethyl]-imidazole mononitrate. CAS-68797-31-9; CAS-27220-47-9 (econazole)(1979).
Pharmacologic Category
Skin and Mucous Membrane Agents; Antifungals; Azoles. Topical Antifungal Agent. (ATC-Code: D01AC03; G01AF05).
Mechanism of action
An imidazole derivative, econazole is a synthetic azole antifungal agent. Alters fungal cell wall membrane permeability. May interfere with RNA and protein synthesis, and lipid metabolism.
Therapeutic use
Treatment of certain dermatophytoses, including tinea corporis (body ringworm), tinea cruris (jock itch), and tinea pedis (athlete’s foot) caused by Epidermophyton floccosum, Microsporum audouinii, M. canis, M. gypseum, Trichophyton mentagrophytes, T. rubrum, or T. tonsurans. Also used for the treatment of pityriasis (tinea) versicolor, a superficial infection caused by Malassezia furfur (Pityrosporum orbiculare or P. ovale), and for the treatment of cutaneous candidiasis caused by Candida albicans.
Pregnancy and lactiation implications
Econazole cream should be used during the 1^st^ trimester of pregnancy only when considered essential to the welfare of the patient and during the 2^nd^ or 3^rd^ trimesters only when clearly needed. Since it is not known whether econazole is distributed into human milk following topical application, it should be used with caution in nursing women.
Unlabeled use
Econazole nitrate has been used effectively for the treatment of vulvovaginal candidiasis. Has also been used with some success as an otic solution for the treatment of otomycoses.
Contraindications
Hypersensitivity to econazole or any component of the formulation.
Warnings and precautions
Irritation. For topical application to the skin only. Should not be applied to the eye or administered intravaginally.