Fexofenadine
- Atc Codes:R06AX26
- CAS Codes:138452-21-8#83799-24-0
- PHARMGKB ID:138452-21-8#83799-24-0
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Toxicological Effects
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Induces
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Telfast; Belgium: Telfast; Bulgaria: Ewofex, Telfast; Cyprus: Telfast; Czech Republic: Afexil, Ewofex, Telfast; Denmark: Nefoxef, Telfast; Finland: Fexofenadine, Nefoxef; France: Fexofenadine, Telfast; Germany: Fexofenadin, Telfast; Greece: Fexofenadine, Telfast; Hungary: Altiva, Ewofex, Fexgen, Fexofenadin, Fexofep, Fexowin, Telfast; Ireland: Fexofenadine, Telfast; Italy: Fexofenadina, Telfast; Latvia: Altiva; Malta: Telfast; Netherlands: Fexofenadine, Telfast; Poland: Eluxat, Ewofex, Fexofast, Fexofenadine, FexoGen, Fexostad, Telfast; Portugal: Fexocare, Fexofenadina, Telfast; Romania: Altiva, Ewofex, Telfast; Slovakia: Ewofex, Fexofenadin, Fixit, Telfast; Slovenia: Ewofex, Feksofenadin, Telfast; Spain: Fexofenadina, Telfast; Sweden: Fexofenadin, Fexofenadine, Nefoxef, Telfast; UK: Telfast.
North America
Canada: Allegra; USA: Allegra.
Latin America
Argentina: Alercas, Alerfedine, Allegra; Brazil: Allegra, Allexofedrin, Altiva, Fexofenadina; Mexico: Aldifex, Allegra, Gebenir.
Asia
Japan: Allegra.
Drug combinations
Fexofenadine and Pseudoephedrine
Chemistry
Fexofenadine Hydrochloride: C~32~H~39~NO~4~ HCl. Mw: 538.12. (1) Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride, (±)-; (2)(±)-p-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl)piperidino]butyl]-α-methylhydratropic acid, hydrochloride. CAS-138452-21-8; CAS-83799-24-0 (fexofenadine)(1995).
Pharmacologic Category
Second Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AX26).
Mechanism of action
Fexofenadine, a second-generation antihistamine, is the active carboxylic acid metabolite of terfenadine. It competes with histamine for H~1~-receptor sites on effector cells in the GI tract, blood vessels and respiratory tract.
Therapeutic use
Fexofenadine is used to relieve the symptoms of hayfever (seasonal allergic rhinitis) such as sneezing, itchy, watery or red eyes, and itchy, blocked or runny nose. Also used to relieve symptoms of perennial allergic rhinitis, a similar allergy which occurs all year round, caused by factors such as house dust, mites, mould and pets.
Pregnancy and lactiation implications
There are no adequate, well-controlled studies in pregnant women. Use during pregnancy only if potential benefit to mother outweighs possible risk to fetus. Use with caution in nursing women.
Unlabeled use
Contraindications
Hypersensitivity to fexofenadine or any component of the formulation.
Warnings and precautions
Risk of overdosage and toxicity (including death) in children <2 years of age receiving over-the-counter preparations containing antihistamines, cough suppressants, expectorants, and nasal decongestants alone or in combination for relief of symptoms of upper respiratory tract infection. Risk of severe adverse reactions may be increased in impaired renal function (fexofenadine is substantially excreted by the kidney). Use with caution in renal impairment. Orally disintegrating tablet (not recommended for use in children <6 years of age) contains phenylalanine.