May alter cardiac conduction (life-threatening arrhythmias have occurred). May cause anticholinergic effects (use with caution in decreased GI motility, paralytic ileus, urinary retention, BPH, xerostomia, or visual problems). Blood dyscrasias might occur (use contraindicated in bone marrow suppression). Esophageal dysmotility or aspiration possible (use with caution in risk of pneumonia). May cause extrapyramidal symptoms, including pseudoparkinsonism, acute dystonic reactions, akathisia, and tardive dyskinesia. Hypotension might occur, particularly with I.M. administration. Neuroleptic malignant syndrome might occur (risk may be increased in Parkinson’s disease or Lewy body dementia). May cause orthostatic hypotension (use with caution in risk of this effect or in patients who would not tolerate transient hypotensive episodes). May be associated with pigmentary retinopathy. May cause sedation. Impaired core body temperature regulation might occur. Use with caution in severe cardiovascular disease, narrow-angle glaucoma, hepatic impairment, myasthenia gravis, Parkinson’s disease, breast cancer or other prolactin-dependent tumors, renal impairment, or respiratory disease. Use with caution in risk of seizures. May mask toxicity of other drugs or conditions (e.g. intestinal obstruction, Reye’s syndrome, brain tumor) due to antiemetic effects. Effects may be potentiated when used with other sedative drugs or ethanol. Use with caution in the elderly (increased risk for developing tardive dyskinesia). Adverse effects of depot injections may be prolonged.