Anaphylactoid reactions might occur (avoid use in patients who experience asthma, bronchospasm, rhinitis, or urticaria with NSAID or aspirin therapy). Bleeding, hemostasis or anemia are possible (use caution in coagulation disorders or patients receiving anticoagulants). Increased risk of adverse cardiovascular thrombotic events, including MI, stroke, and new onset or worsening of pre-existing hypertension (use caution with fluid retention, heart failure, or hypertension). NSAIDs may increase risk of GI irritation, inflammation, ulceration, bleeding, and perforation (use caution with history of GI disease (bleeding or ulcers), concurrent therapy with aspirin, anticoagulants and/or corticosteroids, smoking, use of alcohol, elderly or debilitated patients). NSAIDs may cause serious skin adverse events including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Do not administer to patients with aspirin-sensitive asthma, since severe bronchospasm may occur (use caution in other forms of asthma). Use is contraindicated for treatment of perioperative pain in the setting of CABG surgery. Use with caution in decreased hepatic function. Patients with impaired renal function, dehydration, heart failure, liver dysfunction, those taking diuretics, and ACE inhibitors, and the elderly are at greater risk of renal toxicity. Not recommended for use in advanced renal disease. Long-term NSAID use may result in renal papillary necrosis. The elderly are at increased risk for adverse effects (especially peptic ulceration, CNS effects, renal toxicity) from NSAIDs, even at low doses. Withhold for at least 4-6 half-lives prior to surgical or dental procedures.